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  1. Article

    Open Access

    pyDarwin machine learning algorithms application and comparison in nonlinear mixed-effect model selection and optimization

    Forward addition/backward elimination (FABE) has been the standard for population pharmacokinetic model selection (PPK) since NONMEM® was introduced. We investigated five machine learning (ML) algorithms (Gene...

    **nnong Li, Mark Sale, Keith Nieforth… in Journal of Pharmacokinetics and Pharmacody… (2024)

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  2. No Access

    Article

    Pharmacokinetics, Pharmacodynamics and Drug Interaction Potential of Enfuvirtide

    Enfuvirtide, the first fusion inhibitor approved for the treatment of HIV-1 infection, is a synthetic peptide that binds to HIV-1 glycoprotein 41, blocking the fusion of viral and cellular membranes. When admi...

    Dr Indravadan H. Patel, ** Zhang, Keith Nieforth… in Clinical Pharmacokinetics (2005)