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  1. Article

    Open Access

    Production and properties of adhesin-free gingipain proteinase RgpA

    The Arg-specific gingipains of Porphyromonas gingivalis RgpA and RgpB have 97% identical sequences in their catalytic domains yet their propeptides are only 76% identical. RgpA isolates as a proteinase–adhesin co...

    Abu Sayeed M. Mahmud, Christine A. Seers, N. Laila Huq, Lianyi Zhang… in Scientific Reports (2023)

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  2. Chapter and Conference Paper

    Physico-chemical Characterisation of the Processes Involved in Enamel Remineralisation by CPP-ACP

    Casein phosphopeptides derived from tryptic digests of milk caseins spontaneously assemble with calcium and phosphate ions at high pH to form casein phosphopeptide-amorphous calcium phosphate complexes (CPP-AC...

    Keith J. Cross, N. Laila Huq, Boon Loh, Li-Ming Bhutta… in Biomineralization (2018)

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  3. Article

    Open Access

    A therapeutic Porphyromonas gingivalis gingipain vaccine induces neutralising IgG1 antibodies that protect against experimental periodontitis

    Porphyromonas gingivalis infected mice with an established P. gingivalis-specific inflammatory immune response were protected from develo** alveolar bone resorption by therapeutic vaccination with a chimera (KA...

    Neil M O’Brien-Simpson, James A Holden, Jason C Lenzo, Yan Tan… in npj Vaccines (2016)

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  4. No Access

    Article

    Synthesis and Characterisation of a Multiphosphorylated Phosphophoryn Repeat Motif; H-[Asp-(Ser(P))2]3-Asp-OH

    Protein phosphorylation is a critical mechanism in the regulation of cellular biochemical pathways and phosphopeptides can play an important role in determining function. However, the use of phosphopeptides es...

    Neil M. O’Brien-Simpson, Troy J. Attard… in International Journal of Peptide Research … (2007)

  5. No Access

    Article

    The Role of Multiphosphorylated Peptides in Mineralized Tissue Regeneration

    Several multiple phosphoseryl-containing proteins have been identified in mineralising tissue and body fluids where they have been proposed to act as nucleators and/or regulators of biomineralisation. In parti...

    Keith J. Cross, N. Laila Huq… in International Journal of Peptide Research … (2007)

  6. No Access

    Article

    A Review of the Salivary Proteome and Peptidome and Saliva-derived Peptide Therapeutics

    Saliva is a glandular secretion that is vital in the maintenance of healthy oral tissues. In this review we outline the high abundance salivary proteins, summarise the status of the salivary proteome and pepti...

    N. Laila Huq, Keith J. Cross, Men Ung… in International Journal of Peptide Research … (2007)

  7. No Access

    Article

    Molecular Modelling of a Multiphosphorylated Sequence Motif Bound to Hydroxyapatite Surfaces

    Proteins and peptides containing the multiphosphorylated motif -Ser(P)-Ser(P)- Ser(P)--Glu-Glu- stabilise amorphous calcium phosphate (ACP) in body fluids and bind with high affinity to crystalline calcium phosp...

    N. Laila Huq, Keith J. Cross, Eric C. Reynolds in Molecular modeling annual (2000)

  8. No Access

    Article

    The immunodominant site of a synthetic immunogen has a conformational preference in water for a type-II reverse turn

    Many short synthetic peptides have now been shown to induce antibodies reactive with their cognate sequences in the intact folded protein1–8. Aside from the usefulness of such antibodies as site-specific reagents...

    H. Jane Dyson, Keith J. Cross, Richard A. Houghten, Ian A. Wilson… in Nature (1985)