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Open AccessInfluence of mammographic density and compressed breast thickness on true mammographic sensitivity: a cohort study
Understanding the detectability of breast cancer using mammography is important when considering nation-wide screening programmes. Although the role of imaging settings on image quality has been studied extens...
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Open AccessStudying the association between longitudinal mammographic density measurements and breast cancer risk: a joint modelling approach
Researchers have suggested that longitudinal trajectories of mammographic breast density (MD) can be used to understand changes in breast cancer (BC) risk over a woman’s lifetime. Some have suggested, based on...
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Article
The Evolution of Telepsychiatry for Substance Use Disorders During COVID-19: a Narrative Review
This article aims to review and synthesize the current research evidence regarding the efficacy of telepsychiatry-delivered substance use disorder treatment using a narrative review with a focus on the effects...
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Article
Open AccessAssessing lead time bias due to mammography screening on estimates of loss in life expectancy
An increasingly popular measure for summarising cancer prognosis is the loss in life expectancy (LLE), i.e. the reduction in life expectancy following a cancer diagnosis. The proportion of life lost (PLL) can ...
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How Should the United States Respond to the Opioid Addiction and Overdose Epidemic?
The national epidemic of addiction to and overdose from opioids is the worst public health crisis the United States has faced in decades. The health care system is critical to the public policy response, both ...
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Open AccessAssociation of Microcalcification Clusters with Short-term Invasive Breast Cancer Risk and Breast Cancer Risk Factors
Using for-presentation and for-processing digital mammograms, the presence of microcalcifications has been shown to be associated with short-term risk of breast cancer. In a previous article we developed an al...
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Open AccessGenome-wide association and transcriptome studies identify target genes and risk loci for breast cancer
Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adip...
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Open AccessGenome-wide association study of germline variants and breast cancer-specific mortality
We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry.
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Open AccessLocalized mammographic density is associated with interval cancer and large breast cancer: a nested case-control study
High mammographic density is associated with breast cancer and with delayed detection. We have examined whether localized density, at the site of the subsequent cancer, is independently associated with being d...
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A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer
The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknow...
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Open AccessLong-term prognostic implications of risk factors associated with tumor size: a case study of women regularly attending screening
Breast cancer prognosis is strongly associated with tumor size at diagnosis. We aimed to identify factors associated with diagnosis of large (> 2 cm) compared to small tumors, and to examine implications for l...
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Open AccessCommon genetic variation and novel loci associated with volumetric mammographic density
Mammographic density (MD) is a strong and heritable intermediate phenotype of breast cancer, but much of its genetic variation remains unexplained.
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Correction: Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation
Nature Communications 5: Article number: 4999 (2014); Published: 23 September 2014; Updated: 10 April 2018 The original version of this Article had an incorrect volume number of 4; it should have been 5. This ...
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The Opioid Epidemic as a Watershed Moment for Physician Training in Addiction Medicine
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Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer
Roger Milne and colleagues conduct a genome-wide association study for estrogen receptor (ER)-negative breast cancer combined with BRCA1 mutation carriers in a large cohort. They identify ten new risk variants an...
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Association analysis identifies 65 new breast cancer risk loci
Association analysis identifies 65 new breast cancer risk loci, predicts target genes for known risk loci and demonstrates a strong overlap with somatic driver genes in breast tumours.
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Open AccessBreast Tissue Organisation and its Association with Breast Cancer Risk
Mammographic percentage density is an established and important risk factor for breast cancer. In this paper, we investigate the role of the spatial organisation of (dense vs. fatty) regions of the breast defi...
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Open AccessCommon shared genetic variation behind decreased risk of breast cancer in celiac disease
There is epidemiologic evidence showing that women with celiac disease have reduced risk of later develo** breast cancer, however, the etiology of this association is unclear. Here, we assess the extent of g...
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Open AccessNovel mammographic image features differentiate between interval and screen-detected breast cancer: a case-case study
Interval breast cancers are often diagnosed at a more advanced stage than screen-detected cancers. Our aim was to identify features in screening mammograms of the normal breast that would differentiate between...
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Open AccessIdentification of four novel susceptibility loci for oestrogen receptor negative breast cancer
Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10−8) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated...
