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  1. No Access

    Article

    Role of Tet1 and 5-hydroxymethylcytosine in cocaine action

    Expression of TET1 dioxygenase, which catalyzes the conversion of 5-methylcytosine to 5-hydroxymethylcytosine, is downregulated by repeated cocaine administration in mouse nucleus accumbens, where it controls ...

    Jian Feng, Ningyi Shao, Keith E Szulwach, Vincent Vialou… in Nature Neuroscience (2015)

  2. No Access

    Article

    Genome-wide antagonism between 5-hydroxymethylcytosine and DNA methylation in the adult mouse brain

    Mounting evidence points to critical roles for DNA modifications, including 5-methylcytosine (5mC) and its oxidized forms, in the development, plasticity and disorders of the mammalian nervous system. The nove...

    Junjie U. Guo, Keith E. Szulwach, Yi**g Su, Yu**g Li, Bing Yao… in Frontiers in Biology (2014)

  3. No Access

    Article

    Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency

    Mammalian somatic cells can be directly reprogrammed into induced pluripotent stem cells (iPSCs) by introducing defined sets of transcription factors. Somatic cell reprogramming involves epigenomic reconfigura...

    Tao Wang, Hao Wu, Yu**g Li, Keith E. Szulwach, Li Lin, Xuekun Li… in Nature Cell Biology (2013)

  4. No Access

    Article

    Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing

    5-methylcytosine is an epigenetic mark that affects a broad range of biological functions in mammals. The chemically inert methyl group prevents direct labelling for subsequent affinity purification and detect...

    Liang Zhang, Keith E. Szulwach, Gary C. Hon, … in Nature Communications (2013)

  5. No Access

    Article

    Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine

    A complete understanding of the potential function of 5-hydroxymethylcytosine (5-hmC), a DNA cytosine modification in mammalian cells, requires an accurate single-base resolution sequencing method. Here we des...

    Miao Yu, Gary C Hon, Keith E Szulwach, Chun-**ao Song, Peng **… in Nature Protocols (2012)

  6. No Access

    Article

    5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

    DNA methylation in the context of epigenetics occurs on the 5' position of cytosine, which can be further oxidized by enzymes from the Ten-eleven translocation (Tet) family, resulting in 5-hydroxymethylcytosin...

    Keith E Szulwach, Xuekun Li, Yu**g Li, Chun-**ao Song, Hao Wu… in Nature Neuroscience (2011)

  7. No Access

    Article

    Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

    Song et al. present the first method for global analysis of 5-hydroxymethylcytosine, a recently identified epigenetic modification in mammalian cells. They use a bacteriophage-derived enzyme to tag the hydroxymet...

    Chun-**ao Song, Keith E Szulwach, Ye Fu, Qing Dai, Chengqi Yi… in Nature Biotechnology (2011)

  8. No Access

    Article

    A small molecule enhances RNA interference and promotes microRNA processing

    Little is known about the regulation of RNA interference (RNAi). Shan et al. constructed a reporter system to monitor RNAi activity and identified a small molecule that increases RNAi by facilitating the interact...

    Ge Shan, Yu**g Li, Junliang Zhang, Wendi Li, Keith E Szulwach… in Nature Biotechnology (2008)