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  1. Article

    Role of the cGAS–STING pathway in systemic and organ-specific diseases

    Cells are equipped with numerous sensors that recognize nucleic acids, which probably evolved for defence against viruses. Once triggered, these sensors stimulate the production of type I interferons and other...

    Sladjana Skopelja-Gardner, Jie An, Keith B. Elkon in Nature Reviews Nephrology (2022)

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    The (Orf)ull truth about IRF5 and type I interferons in SLE

    Exactly how nucleic acids trigger type I interferon responses via certain Toll-like receptors has been uncertain. Now, a new pathway involving gene products previously linked to systemic lupus erythematosus bu...

    Keith B. Elkon, Tracy A. Briggs in Nature Reviews Rheumatology (2020)

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    Aspirin meets cGAS

    Sensing of cytosolic DNA by cyclic GMP–AMP synthase (cGAS) is central to the pathogenesis of a number of autoinflammatory syndromes and possibly some autoimmune diseases, such as systemic lupus erythematosus (...

    Keith B. Elkon in Nature Reviews Rheumatology (2019)

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    Cytokines as therapeutic targets in SLE

    A number of cytokine pathways are important in the disease process of SLE, and several biological agents for SLE have been developed that target different cytokines or their receptors. This Review discusses th...

    Lars Rönnblom, Keith B. Elkon in Nature Reviews Rheumatology (2010)