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  1. No Access

    Article

    Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

    Lupus-like disease is driven by NETs enriched in mitochondrial DNA.

    Christian Lood, Luz P Blanco, Monica M Purmalek, Carmelo Carmona-Rivera… in Nature Medicine (2016)

  2. No Access

    Article

    Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature

    Yanick Crow and colleagues show that mutations in ACP5, which encodes tartrate-resistant acid phosphatase, cause spondyloenchondrodysplasia, a bone dysplasia with autoimmunity. The affected individuals had elevat...

    Tracy A Briggs, Gillian I Rice, Sarah Daly, Jill Urquhart… in Nature Genetics (2011)

  3. No Access

    Article

    Autoimmunity: apoptotic fats grease transcription

    Transcription factors known for handling the body's response to lipids promote clearance of apoptotic cells by macrophages, according to new research (pages 1266–1272

    Keith B Elkon in Nature Medicine (2009)

  4. No Access

    Article

    IL-1α responds to necrotic cell death

    Necrosis induces inflammation, but how necrotic cells signal to immune cells was poorly understood. New work by Chen et al. shows that IL-1α acts as a mediator, translating a signal from the necrotic cells to ind...

    Keith B Elkon in Nature Medicine (2007)