-
Article
Open AccessNumber of Attending Physicians and Accumulated Organ Damage in Patients with Systemic Lupus Erythematosus: LUNA Registry Cross-Sectional Study
Patients with systemic lupus erythematosus (SLE) frequently change attending physicians. The number of changes in attending physicians is related to the accumulated organ damage in patients with diabetes melli...
-
Article
Open AccessHLA-B52 allele in giant cell arteritis may indicate diffuse large-vessel vasculitis formation: a retrospective study
This study aimed to identify new characteristics of elderly onset large-vessel vasculitis (EOLVV) by focusing on human leucocyte antigen (HLA) genotype, polymyalgia rheumatica (PMR), and affected vascular lesi...
-
Article
Rapid Flow Cytometry-Based Assay for the Functional Classification of MEFV Variants
Pathogenic MEFV variants cause pyrin-associated autoinflammatory diseases (PAADs), which include familial Mediterranean fever (FMF), FMF-like disease, and pyrin-associated autoinflammation with neutrophilic derma...
-
Article
Shoulder ultrasound and serum lactate dehydrogenase predict inadequate response to glucocorticoid treatment in patients with polymyalgia rheumatica
We aimed to identify predictors of inadequate response to glucocorticoid (GC) treatment in patients with polymyalgia rheumatica (PMR). We retrospectively studied 32 patients as a derivation cohort and 24 patie...
-
Article
Genetic and clinical prediction models for the efficacy and hepatotoxicity of methotrexate in patients with rheumatoid arthritis: a multicenter cohort study
The objective of the study is to develop genetic and clinical prediction models for the efficacy and hepatotoxicity of methotrexate (MTX) in patients with rheumatoid arthritis (RA). Among RA patients treated w...
-
Article
Open AccessTofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates interstitial lung disease in SKG mice
Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a sometimes life-threatening complication in RA patients. SKG mice develop not only arthritis but also an ILD resembling RA-ILD. We previou...
-
Article
Open AccessAdditive effects of inhibiting both mTOR and glutamine metabolism on the arthritis in SKG mice
Glutamine metabolism and the mechanistic target of rapamycin (mTOR) pathway are activated cooperatively in the differentiation and activation of inflammatory immune cells. But the combined inhibition of both p...
-
Article
Open AccessSerological and morphological prognostic factors in patients with interstitial pneumonia with autoimmune features
To identify the prognostic factors for survival in patients with interstitial pneumonia with autoimmune features (IPAF) who meet the serological domain of the IPAF criteria.
-
Article
Open Access3-bromopyruvate ameliorate autoimmune arthritis by modulating Th17/Treg cell differentiation and suppressing dendritic cell activation
Recent studies have shown that cellular metabolism plays an important role in regulating immune cell functions. In immune cell differentiation, both interleukin-17-producing T (Th17) cells and dendritic cells ...
-
Article
Open AccessKnockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice
Endothelin-1 (ET-1) is important in the pathogenesis of systemic sclerosis (SSc). ET-1 binds two receptors, endothelin type A (ETA) and endothelin type B (ETB). Dual ETA/ETB receptor antagonists and a selective E...
-
Article
Localization phenomena in torsional rotating shaft systems with multiple centrifugal pendulum vibration absorbers
The behavior of multiple centrifugal pendulum vibration absorbers (CPVAs) is investigated when they are installed on a rotor in order to suppress torsional vibrations of an elastic, rotating shaft. Linear tors...
-
Article
Margin-negative limited resection of metastatic pancreatic tumors from rectal cancer preoperatively diagnosed by endoscopic ultrasound-guided fine-needle aspiration biopsies: report of two cases
Pancreatic tumor metastasis from colorectal cancer is very rare. This study evaluated the significance of an endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) and surgical treatment. Case 1...
-
Article
Mycophenolate mofetil versus intravenous cyclophosphamide for induction treatment of proliferative lupus nephritis in a Japanese population: a retrospective study
Recent studies have shown that mycophenolate mofetil (MMF) is similar to intravenous cyclophosphamide (IVC) for the treatment of lupus nephritis (LN), but that treatment response may vary according to location...
-
Article
Nonalcoholic steatohepatitis (NASH) after pancreaticoduodenectomy: association of pancreatic exocrine deficiency and infection
Previous clinical study has demonstrated that 30–40% of patients undergoing pancreaticoduodenectomy (PD) developed hepatic steatosis. However, nonalcoholic steatohepatitis (NASH) is a little-known complication...
-
Article
Role of imaging studies in the diagnosis and evaluation of giant cell arteritis in Japanese: report of eight cases
The objective of this study is to clarify the characteristics and imaging results of Japanese patients with giant cell arteritis (GCA). Eight patients with biopsy-proven GCA were enrolled. Their clinical data ...
-
Chapter and Conference Paper
BDI Model-Based Crowd Simulation
We present a new approach for crowd simulation in which a BDI (Belief-Desire-Intention) model is introduced that makes it possible for a character in a simulated environment to work adaptively. Our approach al...
-
Article
Concentrations and Distribution of Mercury and Other Heavy Metals in Surface Sediments of the Yatsushiro Sea including Minamata Bay, Japan
The concentrations and distribution of heavy metals, such as mercury, zinc, copper, lead, and iron in surface sediments from 234 stations of the Yatsushiro Sea including Minamata bay were investigated. High co...
-
Article
Identification of high-risk breast cancer patients from genetic changes of their tumors
To identify the genetic prognostic markers for breast cancer, we analyzed loss of heterozygosity (LOH) at 11p, 16q, 17p, 17q, and 18q, as well as amplification of theERBB2, INT2, andMYC genes, in 131 patients wit...
-
Article
Comparison of p53 and bcl-2 expression in initial, synchronous, and metachronous colorectal adenomas
To investigate the significance of p53 and bcl-2 expression in metachronous colorectal adenomas arising in the remaining colon after carcinoma resection, we analyzed p53 and bcl-2 expression immunohistochemica...
