-
Article
A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf–Hirschhorn syndrome
Histone H3 trimethylation at lysine 36 (H3K36me3) is associated with actively transcribed regions and has been proposed to provide landmarks for ongoing transcription. Here, an H3K36me3-specific histone methyl...
-
Article
Histone methyltransferases: regulation of transcription and contribution to human disease
Histone modifications contribute to the precise regulation of transcription by recruiting non-histone proteins and controlling chromatin conformation. These covalent modifications are dynamically regulated by ...
-
Article
Immunogene therapy using immunomodulating HVJ-E vector augments anti-tumor effects in murine malignant glioma
The hemagglutinating virus of Japan envelope (HVJ-E) vector derived from inactivated replication-defective Sendai virus enhances anti-tumor immunity through activation of effector T cells and natural killer (N...
-
Article
Open AccessNANOG helps cancer cells escape NK cell attack by downregulating ICAM1 during tumorigenesis
At the beginning of tumorigenesis, newly born cancer cells must successfully avoid attack by the immune system. Although most abnormal cells are efficiently identified and destroyed by the immune system, parti...
-
Article
Open AccessEvaluation of HPV16 E7 expression in head and neck carcinoma cell lines and clinical specimens
Human papillomavirus (HPV) 16 infection in the oropharynx is one of the major risk factors for oropharyngeal carcinoma. Although the HPV E6 and E7 proteins are known to have a role in head and neck carcinogene...
-
Article
Open AccessA simple method using CRISPR-Cas9 to knock-out genes in murine cancerous cell lines
CRISPR-Cas9 system can be used to generate knock-out cancer cell lines. An insertion or deletion induced by a single guide RNA (gRNA) is often used to generate knock-out cells, however, some cells express the ...
-
Article
Open AccessAuthor Correction: Evaluation of HPV16 E7 expression in head and neck carcinoma cell lines and clinical specimens
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Open AccessDual function of SF3B2 on chromatin and RNA to regulate transcription in head and neck squamous cell carcinoma
RNA is spliced concomitantly with transcription and the process is organized by RNA splicing factors, transcriptional regulators, and chromatin regulators. RNA is spliced in close proximity to transcription ma...
-
Article
Open AccessDNA barcoding and gene expression recording reveal the presence of cancer cells with unique properties during tumor progression
Tumors comprise diverse cancer cell populations with specific capabilities for adaptation to the tumor microenvironment, resistance to anticancer treatments, and metastatic dissemination. However, whether thes...
-
Article
Open AccessGREB1 isoform 4 is specifically transcribed by MITF and required for melanoma proliferation
Growth regulation by estrogen in breast cancer 1 (GREB1) is involved in hormone-dependent and -independent tumor development (e.g., hepatoblastoma). In this study, we found that a GREB1 splicing variant, isofo...
