7 Result(s)
within
Keisuke Ito
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessResilient anatomy and local plasticity of naive and stress haematopoiesis
The bone marrow adjusts blood cell production to meet physiological demands in response to insults. The spatial organization of normal and stress responses are unknown owing to the lack of methods to visualize...
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Article
Open AccessAnti-nanodisc antibodies specifically capture nanodiscs and facilitate molecular interaction kinetics studies for membrane protein
Nanodisc technology has dramatically advanced the analysis of molecular interactions for membrane proteins. A nanodisc is designed as a vehicle for membrane proteins that provide a native-like phospholipid env...
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Article
Open AccessA conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity
Land plants produce diverse flavonoids for growth, survival, and reproduction. Chalcone synthase is the first committed enzyme of the flavonoid biosynthetic pathway and catalyzes the production of 2′,4,4′,6′-t...
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Article
Open AccessIdentification of soybean peptide leginsulin variants in different cultivars and their insulin-like activities
We have recently reported that green soybean cultivar, echigomidori, and not the yellow cultivar, fukuyutaka, is a rich source of hormone-like peptide leginsulin consisting of 37 amino acids (Leg_1_37, PDB 1JU8A)...
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Article
Open AccessA non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
Disease recurrence after therapy, due to the persistence of resistant leukemic cells, represents a fundamental problem in the treatment of leukemia. Elucidating the mechanisms responsible for the maintenance o...
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Article
Open AccessImage-guided transplantation of single cells in the bone marrow of live animals
Transplantation of a single hematopoietic stem cell is an important method for its functional characterization, but the standard transplantation protocol relies on cell homing to the bone marrow after intraven...
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Article
Open AccessAnalysing the substrate multispecificity of a proton-coupled oligopeptide transporter using a dipeptide library
Peptide uptake systems that involve members of the proton-coupled oligopeptide transporter (POT) family are conserved across all organisms. POT proteins have characteristic substrate multispecificity, with whi...
