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A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance
Keisuke Ito et al. uncover a new pathway regulating hematopoietic stem cell maintenance and function. In this pathway, the promyelocytic leukemia protein (PML) regulates the activity of the PPAR-δ nuclear hormone...
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Correction: Corrigendum: Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
Nat. Med. 12, 446–451 (2006); published online 26 March 2006; corrected after print 7 January 2010 In the version of this article initially published, two micrographs in Figure 2c, corresponding to the conditi...
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Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
Hematopoietic stem cells (HSCs) undergo self-renewing cell divisions and maintain blood production for their lifetime1. Appropriate control of HSC self-renewal is crucial for the maintenance of hematopoietic home...