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Article
Open AccessProteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks
Despite the wide effects of cardiorespiratory fitness (CRF) on metabolic, cardiovascular, pulmonary and neurological health, challenges in the feasibility and reproducibility of CRF measurements have impeded i...
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Article
Open AccessAssociation between retinal microvascular abnormalities and late-life brain amyloid-β deposition: the ARIC-PET study
Retinal microvascular signs are accessible measures of early alterations in microvascular dysregulation and have been associated with dementia; it is unclear if they are associated with AD (Alzheimer’s disease...
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Article
Open AccessAlzheimer’s and neurodegenerative disease biomarkers in blood predict brain atrophy and cognitive decline
Although blood-based biomarkers have been identified as cost-effective and scalable alternatives to PET and CSF markers of neurodegenerative disease, little is known about how these biomarkers predict future b...
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Article
Open AccessAssociations between genetically predicted plasma protein levels and Alzheimer’s disease risk: a study using genetic prediction models
Specific peripheral proteins have been implicated to play an important role in the development of Alzheimer’s disease (AD). However, the roles of additional novel protein biomarkers in AD etiology remains elus...
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Article
Open AccessThe role of peripheral inflammatory insults in Alzheimer’s disease: a review and research roadmap
Peripheral inflammation, defined as inflammation that occurs outside the central nervous system, is an age-related phenomenon that has been identified as a risk factor for Alzheimer’s disease. While the role o...
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Article
Open AccessCorrection to: Plasma proteins related to inflammatory diet predict future cognitive impairment
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Article
Open AccessPlasma proteins related to inflammatory diet predict future cognitive impairment
Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the develo...