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Article
Methylation class oligosarcoma, IDH-mutant could exhibit astrocytoma-like molecular features
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Article
Open AccessMechanistic study on the side arm effect in a palladium/Xu-Phos-catalyzed enantioselective alkoxyalkenylation of γ-hydroxyalkenes
Recently, the asymmetric bifunctionalization of alkenes has received much attention. However, the development of enantioselective alkoxyalkenylation has posed a considerable challenge and has lagged largely be...
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Article
Open AccessMolecular and clinical characterization of PTRF in glioma via 1,022 samples
Polymerase I and transcript release factor (PTRF) plays a role in the regulation of gene expression and the release of RNA transcripts during transcription, which have been associated with various human diseases....
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Article
Open AccessMET fusions and splicing variants convergently define a subgroup of glioma sensitive to MET inhibitors
Our previous study has shown that PTPRZ1-MET (ZM) fusion is a viable target for MET inhibitors in gliomas. However, the diversity and prevalence of somatic MET alterations in diffuse gliomas are still elusive and...
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Article
Open AccessWES data from 286 diffuse gliomas under the 2021 WHO Classification of Tumors of the Central Nervous System
Diffuse gliomas (DGs) are the most common and lethal primary neoplasms in the central nervous system. The latest 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS...
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Article
Open AccessYTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m6A modification to activate NF-κB and promote the malignant progression of glioma
The prognosis for diffuse gliomas is very poor and the mechanism underlying their malignant progression remains unclear. Here, we aimed to elucidate the role and mechanism of the RNA N6,2′-O-dimethyladenosine (m6
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Article
Open AccessSystematically profiling the expression of eIF3 subunits in glioma reveals the expression of eIF3i has prognostic value in IDH-mutant lower grade glioma
Abnormal expression of the eukaryotic initiation factor 3 (eIF3) subunits plays critical roles in tumorigenesis and progression, and also has potential prognostic value in cancers. However, the expression and ...
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Article
A second-order nonlinear optical dendronized hyperbranched polymer containing isolation chromophores: achieving good optical nonlinearity and stability simultaneously
Large nonlinear optical (NLO) coefficient and good stability, two essential factors to evaluate second-order NLO materials, are difficult to be achieved in one molecule simultaneously. Herein, by utilizing the...
