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  1. No Access

    Book

    Ketamine

    From Abused Drug to Rapid-Acting Antidepressant

    Kenji Hashimoto, Soichiro Ide, Kazutaka Ikeda (2020)

  2. No Access

    Chapter

    Distinct Roles of NMDA Receptor GluN2 Subunits in the Effects of Ketamine and Its Enantiomers

    The N-methyl-d-aspartate (NMDA) receptor antagonist ketamine is known to induce various pharmacological effects. It has attracted attention because of its rapid and sustained antidepressant effects in depressed p...

    Soichiro Ide, Kazutaka Ikeda in Ketamine (2020)

  3. Article

    Open Access

    Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl

    The P2X7 receptor is a member of the P2X family of adenosine 5′-triphosphate-gated cation channels. Several recent studies have demonstrated that this receptor is involved in mechanisms related to pain and inflam...

    Soichiro Ide, Daisuke Nishizawa, Ken-ichi Fukuda, Shinya Kasai… in Molecular Pain (2014)

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  4. Article

    Open Access

    Genome-wide association study of sensory disturbances in the inferior alveolar nerve after bilateral sagittal split ramus osteotomy

    Bilateral sagittal split ramus osteotomy (BSSRO) is a common orthognatic surgical procedure. Sensory disturbances in the inferior alveolar nerve, including hypoesthesia and dysesthesia, are frequently observed...

    Daisuke Kobayashi, Daisuke Nishizawa, Yoshito Takasaki, Shinya Kasai… in Molecular Pain (2013)

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  5. Article

    Open Access

    (-)-Pentazocine induces visceral chemical antinociception, but not thermal, mechanical, or somatic chemical antinociception, in μ-opioid receptor knockout mice

    (-)-Pentazocine has been hypothesized to induce analgesia via the κ-opioid (KOP) receptor, although the involvement of other opioid receptor subtypes in the effects of pentazocine remains unknown. In this stud...

    Soichiro Ide, Masabumi Minami, George R Uhl, Masamichi Satoh, Ichiro Sora… in Molecular Pain (2011)

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  6. No Access

    Article

    Ethanol opens G-protein-activated inwardly rectifying K+ channels

    Ethanol affects many functions of the brain and peripheral organs. Here we show that ethanol opens G-protein-activated, inwardly rectifying K+ (GIRK) channels, which has important implications for inhibitory regu...

    Toru Kobayashi, Kazutaka Ikeda, Hiroshi Kojima, Hiroaki Niki… in Nature Neuroscience (1999)