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Article
Influence of slippage reduction and correction of lumbosacral kyphosis by single-level posterior lumbar interbody fusion on spinal alignment in patients with dysplastic spondylolisthesis
To investigate the influence of slippage reduction and correction of lumbosacral kyphosis by L5–S1 single-level posterior lumbar interbody fusion (PLIF) on spinal alignment and clinical outcomes including post...
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Article
Neurological recovery rate and predictive factors of incomplete AIS grade C spinal cord injury in the older aged population
Retrospective cohort study.
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Article
Open AccessImpact of malnutrition on mortality and neurological recovery of older patients with spinal cord injury
This retrospective cohort study established malnutrition’s impact on mortality and neurological recovery of older patients with cervical spinal cord injury (SCI). It included patients aged ≥ 65 years with trau...
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Article
Prognostic impact of respiratory dysfunction in elderly patients with cervical spinal cord injury and/or fractures: a multicenter survey
To investigate the impact of early post-injury respiratory dysfunction for neurological and ambulatory ability recovery in patients with cervical spinal cord injury (SCI) and/or fractures.
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Article
Open AccessStructure of a putative immature form of a Rieske-type iron-sulfur protein in complex with zinc chloride
Iron-sulfur clusters are prosthetic groups of proteins involved in various biological processes. However, details of the immature state of the iron-sulfur cluster into proteins have not yet been elucidated. We...
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Article
Open AccessDetailed analysis of distorted retinal and its interaction with surrounding residues in the K intermediate of bacteriorhodopsin
The K intermediate of proton pum** bacteriorhodopsin is the first intermediate generated after isomerization of retinal to the 13-cis form. Although various structures have been reported for the K intermediate ...
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Article
Open AccessCharacteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament
Although the incidence of cervical spinal cord injury (CSCI) with ossification of the posterior longitudinal ligament (OPLL) has increased in older adults, its etiology and neurological outcomes remain unknown...
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Article
Open AccessObservation of hapten-induced sensitization responses for the development of a mouse skin sensitization test, including the elicitation phase
The only official method that can detect the skin sensitizing potential of chemicals, including the elicitation response, is the OECD test guideline (TG) 406. However, this guideline uses guinea pigs, which re...
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Article
Does surgery improve neurological outcomes in older individuals with cervical spinal cord injury without bone injury? A multicenter study
Retrospective multicenter study.
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Article
Open AccessA multicenter study of 1-year mortality and walking capacity after spinal fusion surgery for cervical fracture in elderly patients
The 1-year mortality and functional prognoses of patients who received surgery for cervical trauma in the elderly remains unclear. The aim of this study is to investigate the rates of, and factors associated w...
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Article
Activation of transient receptor potential vanilloid 4 channels dilates rat retinal arterioles through nitric oxide- and BKCa channel-dependent mechanisms in vivo
Transient receptor potential vanilloid 4 (TRPV4) channel, a cation channel expressed in nearly all cell types, plays an important role in the regulation of vascular tone. In the present study, we examined the ...
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Article
Open AccessGenome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese
Adolescent idiopathic scoliosis (AIS) is the most common pediatric spinal deformity. Several AIS susceptibility loci have been identified; however, they could explain only a small proportion of AIS heritabilit...
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Article
Open AccessX-ray structure analysis of bacteriorhodopsin at 1.3 Å resolution
Bacteriorhodopsin (bR) of Halobacterium salinarum is a membrane protein that acts as a light-driven proton pump. bR and its homologues have recently been utilized in optogenetics and other applications. Although ...
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Article
Open AccessA multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis
Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associ...
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Article
Open AccessAn international meta-analysis confirms the association of BNC2 with adolescent idiopathic scoliosis
Adolescent idiopathic scoliosis (AIS) is a common spinal deformity with the prevalence of approximately 3%. We previously conducted a genome-wide association study (GWAS) using a Japanese cohort and identified...
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Chapter
The Genetics Contributing to Disorders Involving Congenital Scoliosis
Congenital scoliosis (CS) is a congenital deformity of the spine, which can present as an isolated malformation, or part of a syndrome with other clinical features such as renal, cardiac, gastrointestinal, and...
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Article
Open AccessDistribution of valence electrons of the flavin cofactor in NADH-cytochrome b5 reductase
Flavin compounds such as flavin adenine dinucleotide (FAD), flavin mononucleotide and riboflavin make up the active centers in flavoproteins that facilitate various oxidoreductive processes. The fine structura...
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Article
Open AccessStructural studies of the N-terminal fragments of the WW domain: Insights into co-translational folding of a beta-sheet protein
Nascent proteins fold co-translationally because the folding speed and folding pathways are limited by the rate of ribosome biosynthesis in the living cell. In addition, though full-length proteins can fold al...
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Article
Charge-density analysis of an iron–sulfur protein at an ultra-high resolution of 0.48 Å
The ultra-high-resolution structure of the high-potential iron–sulfur protein at 0.48 Å, the highest-resolution X-ray crystal structure of a protein reported so far.
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Article
Evaluation of the effects of subject thickness on the exposure index in digital radiography
The exposure index (EI) was proposed as a new X-ray dose index by the International Electrotechnical Commission (IEC) and has since been implemented as an international standard. The EI is calculated by use of...
