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Article
Open AccessAssociation of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus
CD226 is an activating receptor expressed on the cell surface of natural killer cells and T cells. Although CD226 polymorphism is known to be involved in systemic lupus erythematosus (SLE), the involvement of ...
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Article
Open AccessAssociation of circulating SLAMF7+Tfh1 cells with IgG4 levels in patients with IgG4-related disease
Follicular helper CD4+ T (Tfh) cells have a critical role in IgG4 production by B cells in IgG4-related disease (IgG4-RD). Recent studies including ours showed that SLAMF7+CD4+ T cells are an important pathologic...
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Article
Open AccessGeneration mechanism of RANKL+ effector memory B cells: relevance to the pathogenesis of rheumatoid arthritis
The efficacy of B cell-depleting therapies for rheumatoid arthritis underscores antibody-independent functions of effector B cells such as cognate T–B interactions and production of pro-inflammatory cytokines....
