-
Article
Open AccessA prognostic neural epigenetic signature in high-grade glioma
Neural–tumor interactions drive glioma growth as evidenced in preclinical models, but clinical validation is limited. We present an epigenetically defined neural signature of glioblastoma that independently pr...
-
Article
Open AccessTranscriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation
Ependymomas encompass multiple clinically relevant tumor types based on localization and molecular profiles. Tumors of the methylation class “spinal ependymoma” (SP-EPN) represent the most common intramedullar...
-
Article
Open AccessTemporal change of DNA methylation subclasses between matched newly diagnosed and recurrent glioblastoma
The longitudinal transition of phenotypes is pivotal in glioblastoma treatment resistance and DNA methylation emerged as an important tool for classifying glioblastoma phenotypes. We aimed to characterize DNA ...
-
Article
Open AccessUnclassifiable CNS tumors in DNA methylation-based classification: clinical challenges and prognostic impact
DNA methylation analysis has become a powerful tool in neuropathology. Although DNA methylation-based classification usually shows high accuracy, certain samples cannot be classified and remain clinically chal...
-
Article
Open AccessTumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo
The immunological composition of the tumor microenvironment has a decisive influence on the biological course of cancer and is therefore of profound clinical relevance. In this study, we analyzed the cooperati...
-
Article
Open AccessGenetic and epigenetic profiling identifies two distinct classes of spinal meningiomas
-
Article
Immune Characterization in Aneurysmal Subarachnoid Hemorrhage Reveals Distinct Monocytic Activation and Chemokine Patterns
The pathophysiology of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) is incompletely understood. Intrathecal activation of inflammatory immune cells is suspected to play a maj...
-
Article
Open AccessCDKN2A/B homozygous deletion is associated with early recurrence in meningiomas
-
Article
Open AccessGenome-wide DNA methylation profiles distinguish silent from non-silent ACTH adenomas
-
Article
Open AccessMolecular profiling of an osseous metastasis in glioblastoma during checkpoint inhibition: potential mechanisms of immune escape
Peripheral metastases of glioblastoma (GBM) are very rare despite the ability of GBM cells to pass through the blood-brain barrier and be disseminated through the peripheral blood. Here, we describe a detailed...
-
Article
Open AccessClonality of circulating tumor cells in breast cancer brain metastasis patients
The incidence of brain metastases in breast cancer (BCBM) patients is increasing. These patients have a very poor prognosis, and therefore, identification of blood-based biomarkers, such as circulating tumor c...
-
Article
Open AccessEGFR and HER3 expression in circulating tumor cells and tumor tissue from non-small cell lung cancer patients
Although clinically relevant, the detection rates of EpCAM positive CTCs in non-small cell lung cancer (NSCLC) are surprisingly low. To find new clinically informative markers for CTC detection in NSCLC, the e...
-
Chapter
Meningiomas and Meningeal Tumors
Meningiomas are a major group of intracranial neoplasms. According to the WHO classification, they are subdivided into three grades with increasing anaplasia, grade I being the commonest (about 80%) followed b...
-
Article
Chordoid meningiomas can be sub-stratified into prognostically distinct DNA methylation classes and are enriched for heterozygous deletions of chromosomal arm 2p
-
Article
The natural HLA ligandome of glioblastoma stem-like cells: antigen discovery for T cell-based immunotherapy
Glioblastoma is the most frequent malignant primary brain tumor. In a hierarchical tumor model, glioblastoma stem-like cells (GSC) play a major role in tumor initiation and maintenance as well as in therapy re...
-
Article
Open AccessEGFR as a Target for Glioblastoma Treatment: An Unfulfilled Promise
The receptor for epidermal growth factor (EGFR) is a prime target for cancer therapy across a broad variety of tumor types. As it is a tyrosine kinase, small molecule tyrosine kinase inhibitors (TKIs) targetin...
-
Article
Open AccessCirculating Tumour Cell Release after Cement Augmentation of Vertebral Metastases
Cement augmentation via percutaneous vertebroplasty or kyphoplasty for treatment of spinal metastasis is a well-established treatment option. We assessed whether elevated intrametastatic pressure during cement...
-
Article
Glioblastoma Cell Type-Specific Loading with Iron Oxide Magnetic Nanoparticles
Magnetic nanoparticles (MNPs) could support the traditional brain cancer (e.g., glioblastoma) therapy; however, the efficient cell loading remains a crucial point. We aimed to relate the impact of the in vitro...
-
Article
Histone Deacetylase Inhibitors Resensitize EGFR/EGFRvIII-Overexpressing, Erlotinib-Resistant Glioblastoma Cells to Tyrosine Kinase Inhibition
Although the epidermal growth factor receptor (EGFR) is overexpressed and/or amplified in more than 50 % of all glioblastomas (GBM), therapeutic targeting of the EGFR has not yet been successful. Since histone...
-
Article
Circulating biomarkers for gliomas
Biomarkers from gliomas can be detected in the blood and cerebrospinal fluid
Known mutations, such as the e...
