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    Reference Work Entry In depth

    Ceramide

    Katrin Anne Becker, Erich Gulbins in Encyclopedia of Cancer (2017)

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    Article

    Melanoma cell metastasis via P-selectin-mediated activation of acid sphingomyelinase in platelets

    Metastatic dissemination of cancer cells is one of the hallmarks of malignancy and accounts for approximately 90 % of human cancer deaths. Within the blood vasculature, tumor cells may aggregate with platelets...

    Katrin Anne Becker, Nadine Beckmann, Constantin Adams… in Clinical & Experimental Metastasis (2017)

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    Living Reference Work Entry In depth

    Ceramide

    Katrin Anne Becker, Erich Gulbins in Encyclopedia of Cancer

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    Chapter

    Acid Sphingomyelinase

    The enzyme acid sphingomyelinase catalyzes the hydrolysis of sphingomyelin to ceramide. The importance of the enzyme for cell functions was first recognized in Niemann–Pick disease type A and B, the genetic di...

    Brian Henry, Regan Ziobro… in Sphingolipids: Basic Science and Drug Deve… (2013)