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Article
Open AccessAcid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma
Pancreatic adenocarcinoma (PDAC) is one of the most common cancers worldwide. Unfortunately, the prognosis of PDAC is rather poor, and for instance, in the USA, over 47,000 people die because of pancreatic can...
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Article
Open AccessSimultaneous targeting of mitochondrial Kv1.3 and lysosomal acid sphingomyelinase amplifies killing of pancreatic ductal adenocarcinoma cells in vitro and in vivo
Pancreas ductal adenocarcinoma (PDAC) remains a malignant tumor with very poor prognosis and low 5-year overall survival. Here, we aimed to simultaneously target mitochondria and lysosomes as a new treatment p...
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Article
Open AccessStress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma
Major depressive disorder (MDD) is a very common, severe disease with a lifetime prevalence of ~ 10%. The pathogenesis of MDD is unknown and, unfortunately, therapy is often insufficient. We have previously re...
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Article
Comorbid medical conditions are a key factor to understand the relationship between psychiatric disorders and COVID-19-related mortality: Results from 49,089 COVID-19 inpatients
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Article
Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19: current evidence and potential mechanisms
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Article
Open AccessAcid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease
Macrophages have important protective functions during infection with herpes simplex virus type 1 (HSV-1). However, molecular mechanisms that restrict viral propagation and protect from severe disease are uncl...
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Article
Open AccessSphingosine is able to prevent and eliminate Staphylococcus epidermidis biofilm formation on different orthopedic implant materials in vitro
Periprosthetic infection (PPI) is a devastating complication in joint replacement surgery. On the background of an aging population, the number of joint replacements and associated complications is expected to...
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Reference Work Entry In depth
Role of Sphingolipids in Bacterial Infections
Lipids play a very important role in the infection of mammalian cells by different pathogens. Sphingolipids have been shown by numerous recent studies to possess a particularly essential role in infectious biolog...
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Article
Open AccessSphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia
Ventilator-associated pneumonia (VAP) is a major cause of morbidity and mortality in critically ill patients. Here, we employed the broad antibacterial effects of sphingosine to prevent VAP by develo** a nov...
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Living Reference Work Entry In depth
Role of Sphingolipids in Bacterial Infections
Lipids play a very important role in the infection of mammalian cells by different pathogens. Sphingolipids have been shown by numerous recent studies to possess a particularly essential role in infectious biolog...
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Article
Antidepressants regulate autophagy by targeting acid sphingomyelinase
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Article
Open AccessAntidepressants act by inducing autophagy controlled by sphingomyelin–ceramide
Major depressive disorder (MDD) is a common and severe disease characterized by mood changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the molecular mechanism of their a...
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Reference Work Entry In depth
Sphingomyelinase, Acidic
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Reference Work Entry In depth
Ceramide
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Article
Melanoma cell metastasis via P-selectin-mediated activation of acid sphingomyelinase in platelets
Metastatic dissemination of cancer cells is one of the hallmarks of malignancy and accounts for approximately 90 % of human cancer deaths. Within the blood vasculature, tumor cells may aggregate with platelets...
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Living Reference Work Entry In depth
Sphingomyelinase, Acidic
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Article
Open AccessAcid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis
Pulmonary edema associated with increased vascular permeability is a severe complication of Staphylococcus aureus–induced sepsis and an important cause of human pathology and death. We investigated the role of th...
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Article
Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice
Decoy liposomes that bind and sequester bacterial exotoxins can be used to combat septicemia and infection.
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Living Reference Work Entry In depth
Ceramide
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Chapter
Acid Sphingomyelinase
The enzyme acid sphingomyelinase catalyzes the hydrolysis of sphingomyelin to ceramide. The importance of the enzyme for cell functions was first recognized in Niemann–Pick disease type A and B, the genetic di...
