12 Result(s)
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Article
Open AccessAcid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma
Pancreatic adenocarcinoma (PDAC) is one of the most common cancers worldwide. Unfortunately, the prognosis of PDAC is rather poor, and for instance, in the USA, over 47,000 people die because of pancreatic can...
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Article
Open AccessSimultaneous targeting of mitochondrial Kv1.3 and lysosomal acid sphingomyelinase amplifies killing of pancreatic ductal adenocarcinoma cells in vitro and in vivo
Pancreas ductal adenocarcinoma (PDAC) remains a malignant tumor with very poor prognosis and low 5-year overall survival. Here, we aimed to simultaneously target mitochondria and lysosomes as a new treatment p...
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Article
Open AccessStress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma
Major depressive disorder (MDD) is a very common, severe disease with a lifetime prevalence of ~ 10%. The pathogenesis of MDD is unknown and, unfortunately, therapy is often insufficient. We have previously re...
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Article
Open AccessSphingosine is able to prevent and eliminate Staphylococcus epidermidis biofilm formation on different orthopedic implant materials in vitro
Periprosthetic infection (PPI) is a devastating complication in joint replacement surgery. On the background of an aging population, the number of joint replacements and associated complications is expected to...
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Article
Open AccessSphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia
Ventilator-associated pneumonia (VAP) is a major cause of morbidity and mortality in critically ill patients. Here, we employed the broad antibacterial effects of sphingosine to prevent VAP by develo** a nov...
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Reference Work Entry In depth
Sphingomyelinase, Acidic
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Reference Work Entry In depth
Ceramide
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Living Reference Work Entry In depth
Sphingomyelinase, Acidic
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Article
Open AccessAcid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis
Pulmonary edema associated with increased vascular permeability is a severe complication of Staphylococcus aureus–induced sepsis and an important cause of human pathology and death. We investigated the role of th...
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Living Reference Work Entry In depth
Ceramide
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Chapter
Acid Sphingomyelinase
The enzyme acid sphingomyelinase catalyzes the hydrolysis of sphingomyelin to ceramide. The importance of the enzyme for cell functions was first recognized in Niemann–Pick disease type A and B, the genetic di...
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Article
Role of CD95 in pulmonary inflammation and infection in cystic fibrosis
Cystic fibrosis is caused by a defective expression of the cystic fibrosis transmembrane conductance regulator (Cftr) gene, which results in chronic pulmonary inflammation and infections. The pathophysiological m...
