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Reference Work Entry In depth
Ceramide
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Article
Melanoma cell metastasis via P-selectin-mediated activation of acid sphingomyelinase in platelets
Metastatic dissemination of cancer cells is one of the hallmarks of malignancy and accounts for approximately 90 % of human cancer deaths. Within the blood vasculature, tumor cells may aggregate with platelets...
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Living Reference Work Entry In depth
Ceramide
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Chapter
Acid Sphingomyelinase
The enzyme acid sphingomyelinase catalyzes the hydrolysis of sphingomyelin to ceramide. The importance of the enzyme for cell functions was first recognized in Niemann–Pick disease type A and B, the genetic di...
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Chapter
Bacterial Infections and Ceramide
Ceramide is released from sphingomyelin primarily by the activity of acid, neutral, or alkaline sphingomyelinases or is synthesized de novo. Several bacteria, viruses, and even parasites infect mammalian cells...