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Article
ORCHARD: a model for conducting pragmatic randomised trials in pregnancy
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Living Reference Work Entry In depth
Constipation, Diarrhea, and Intestinal Obstruction in Palliative Care
The symptoms of bowel function, including constipation, diarrhea, and bowel obstructions, are problems that commonly affect palliative care patients. This chapter aims to summarize these problems, focusing on ...
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Article
Electronic Health Record Embedded Strategies for Improving Care of Patients With Heart Failure
A majority of clinical decisions use the electronic health record (EHR) and there is an unmet need to use its capability to help providers to make evidence-based decisions that improve care for heart failure p...
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Article
Open AccessDefining research priorities and needs in cancer symptoms for adults diagnosed with cancer: an Australian/New Zealand modified Delphi study
This study asked consumers (patients, carers) and healthcare professionals (HCPs) to identify the most important symptoms for adults with cancer and potential treatment interventions.
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Article
Open AccessExploring biopsychosocial correlates of pregnancy risk and pregnancy intention in women with chronic kidney disease
Women with Chronic Kidney Disease (CKD) are at increased risk of adverse pregnancy and renal outcomes. It is unknown how women with CKD understand their pregnancy risk. This nine-centre, cross-sectional study ...
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Article
Ethnic disparities in pregnancy-related acute kidney injury in a United Kingdom population
The incidence of acute kidney injury in pregnancy (P-AKI) is rising and is associated with detrimental maternal and foetal outcomes. Ethnic disparities in pregnancy outcomes are well recognized, with females w...
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Article
Open AccessPlacental growth fActor Repeat sampling for Reduction of adverse perinatal Outcomes in women with suspecTed pre-eclampsia: study protocol for a randomised controlled trial (PARROT-2)
Pre-eclampsia is a complex pregnancy disorder, characterised by new or worsening hypertension associated with multi-organ dysfunction. Adverse outcomes include eclampsia, liver rupture, stroke, pulmonary oedem...
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Open AccessLessons for the clinical nephrologist: recurrent pregnancy-associated thrombotic microangiopathy (TMA) with a known complement mutation and features of preeclampsia; a diagnostic and therapeutic dilemma
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Article
Open AccessPostnatal assessment for renal dysfunction in women with hypertensive disorders of pregnancy
Hypertensive disorders of pregnancy are associated with chronic kidney disease. Early detection of renal dysfunction enables implementation of strategies to prevent progression. International guidelines recomm...
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Article
Open AccessA randomised, double blind, placebo-controlled trial of megestrol acetate or dexamethasone in treating symptomatic anorexia in people with advanced cancer
This multi-site, double blind, parallel arm, fixed dose, randomised placebo controlled phase III study compared megestrol acetate 480 mg/day with dexamethasone 4 mg/day for their net effects on appetite in peo...
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Article
Open AccessHealth-related quality of life in patients with inoperable malignant bowel obstruction: secondary outcome from a double-blind, parallel, placebo-controlled randomised trial of octreotide
This analysis aims to evaluate health-related quality of life (HrQoL) (primary outcome for this analysis), nausea and vomiting, and pain in patients with inoperable malignant bowel obstruction (IMBO) due to ca...
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Response to Davies A, Leach C, Caponero R, Dickman A, Fuchs D, Paice J, Emmanuel A (2020) MASCC recommendations on the management of constipation in patients with advanced cancer. Support Care Cancer 28:23
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Article
Open AccessTensin1 expression and function in chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) constitutes a major cause of morbidity and mortality. Genome wide association studies have shown significant associations between airflow obstruction or COPD with a...
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Article
Open AccessClinical practice guideline on pregnancy and renal disease
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Reference Work Entry In depth
Gastrointestinal Symptoms: Constipation, Diarrhea, and Intestinal Obstruction
Disturbed bowel function, including constipation, diarrhea, and bowel obstructions, commonly affects palliative care patients. This chapter aims to summarize these problems, focusing on the current understandi...
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Article
Open AccessInducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites
The life cycle of the malaria parasite Plasmodium falciparum is tightly regulated, oscillating between stages of intense proliferation and quiescence. Cyclic 48-hour asexual replication of Plasmodium is markedly ...
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Article
A pragmatic comparative study of palliative care clinician’s reports of the degree of shadowing visible on plain abdominal radiographs
The assessment of constipation symptoms is based on history and physical examination. However, the experience is highly subjective perhaps explaining why palliative medicine doctors continue to use plain abdom...
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Article
Validating self-report and proxy reports of the Dexamethasone Symptom Questionnaire -Chronic for the evaluation of longer-term corticosteroid toxicity
In brain tumours, brain metastases or advanced cancer; treatment with corticosteroids, side effects can add to symptoms. These are best assessed by patients, complementing clinical assessment. We assessed the ...
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Article
Routine prescribing of gabapentin or pregabalin in supportive and palliative care: what are the comparative performances of the medications in a palliative care population?
Neuropathic pain is a prevalent and distressing problem faced by people with life-limiting illness that is often difficult to palliate. Gabapentin and pregabalin are widely prescribed as part of the routine ap...
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Article
Open AccessImproving national hospice/palliative care service symptom outcomes systematically through point-of-care data collection, structured feedback and benchmarking
Every health care sector including hospice/palliative care needs to systematically improve services using patient-defined outcomes. Data from the national Australian Palliative Care Outcomes Collaboration aims...
