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Article
Open AccessPerioperative Opioid Stewardship Program: Barriers and Promotors of Implementation and Sustainability
Perioperative opioid stewardship programs aim to harness the benefits of opioid analgesia for managing acute post-surgical pain whilst mitigating potential harm. Healthcare worker stakeholders are vital for th...
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Article
Open AccessRationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery
For patients undergoing noncardiac surgery, bleeding and hypotension are frequent and associated with increased mortality and cardiovascular complications. Tranexamic acid (TXA) is an antifibrinolytic agent wi...
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Article
Open AccessSugammadex, neostigmine and postoperative pulmonary complications: an international randomised feasibility and pilot trial
Sugammadex reduces residual neuromuscular blockade after anaesthesia, potentially preventing postoperative pulmonary complications. However, definitive evidence is lacking. We therefore conducted a feasibility...
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Article
The effect of perioperative beta-blockers on patients undergoing noncardiac surgery — is the answer in?
The current RCT evidence evaluating the effects of perioperative beta-blocker therapy on short and long-term cardiovascular outcomes has significant limitations. The results of these RCTs should be viewed as p...
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Article
Best evidence in anesthetic practice
In patients undergoing major non-cardiac surgery, what is the efficacy and harm of pharmacological interventions in preventing perioperative myocardial ischemia, nonfatal myocardial infarction (MI), or cardiac...
