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Article
Open AccessThe Effect of Food Intake on the Pharmacokinetics of Oral Basal Insulin: A Randomised Crossover Trial in Healthy Male Subjects
Oral insulin 338 is a novel tablet formulation of a long-acting basal insulin. This randomised, open-label, four-period crossover trial investigated the effect of timing of food intake on the single-dose pharm...
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Article
Nitrogen mustard-mediated mutagenesis in human T-lymphocytes in vitro
The cytotoxic and mutagenic effect of the bifunctional alkylating agent nitrogen mustard (HN2) was examined. Primary human lymphocytes were exposed to graded doses of HN2 in vitro and relative survival was deter...
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Article
Using the relationship between nucleotide sequence and codon usage for the detection of frame-shift sequencing errors in bacterial genes
A simple nucleotide sequence analysis method for the detection of frame-shift sequencing errors is presented. It is based on the fact that the base content of the three positions of the codons in protein-codin...
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Article
Doxorubicin binds in a cooperative manner to myocardial cells
Experimental evidence indicates that the anthracycline antibiotic doxorubicin (adriamycin) localizes mainly in cell nuclei of cardiac cells and has a high affinity to several cellular constituents in addition ...
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Article
Similar changes in cardiac morphology and DNA synthesis induced by doxorubicin and 4′-epi-doxorubicin
Doxorubicin is an antineoplastic agent whose clinical administration is limited by dose-dependent irreversible cardiomyopathy. Doxorubicin inhibits the rate of DNA synthesis in cultured rat myocardial cells af...
