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Article
Open AccessThe FAIR Cookbook - the essential resource for and by FAIR doers
The notion that data should be Findable, Accessible, Interoperable and Reusable, according to the FAIR Principles, has become a global norm for good data stewardship and a prerequisite for reproducibility. Now...
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Article
Open AccessRORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma
RORγt is a transcription factor that enables elaboration of Th17-associated cytokines (including IL-17 and IL-22) and is proposed as a pharmacological target for severe asthma.
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Article
Open AccessCell-specific expression of lung disease risk-related genes in the human small airway epithelium
The human small airway epithelium (SAE) plays a central role in the early events in the pathogenesis of most inherited and acquired lung disorders. Little is known about the molecular phenotypes of the specifi...
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Article
Open AccessIntermittent exposure to whole cigarette smoke alters the differentiation of primary small airway epithelial cells in the air-liquid interface culture
Cigarette smoke (CS) is the leading risk factor to develop COPD. Therefore, the pathologic effects of whole CS on the differentiation of primary small airway epithelial cells (SAEC) were investigated, using ce...
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Article
Open AccessCharacterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity
The pathology of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and most lung cancers involves the small airway epithelium (SAE), the single continuous layer of cells lining ...
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Article
Key factors for successful data integration in biomarker research
Integrating a wide range of biomedical data such as that rapidly emerging from the use of next-generation sequencing is expected to have a key role in identifying and qualifying new biomarkers to support preci...
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Article
Open AccessComparison of normalization methods for Illumina BeadChip HumanHT-12 v3
Normalization of microarrays is a standard practice to account for and minimize effects which are not due to the controlled factors in an experiment. There is an overwhelming number of different methods that c...
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Article
Open AccessEffect of RNA quality on transcript intensity levels in microarray analysis of human post-mortem brain tissues
Large-scale gene expression analysis of post-mortem brain tissue offers unique opportunities for investigating genetic mechanisms of psychiatric and neurodegenerative disorders. On the other hand microarray da...
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Chapter and Conference Paper
Analyzing Microarray Data with the Generative Topographic Map** Approach
The Generative Topographic Map** (GTM) approach of Bishop et al. (1998) is proposed as an alternative to the Self-Organizing Map (SOM) approach of Kohonen (1998) for the analysis of gene expression data from...
