20 Result(s)
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Open AccessFructooligosaccharides benefits on glucose homeostasis upon high-fat diet feeding require type 2 conventional dendritic cells
Diet composition impacts metabolic health and is now recognized to shape the immune system, especially in the intestinal tract. Nutritional imbalance and increased caloric intake are induced by high-fat diet (...
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Open AccessFunctional alterations and predictive capacity of gut microbiome in type 2 diabetes
The gut microbiome plays a significant role in the development of Type 2 Diabetes Mellitus (T2DM), but the functional mechanisms behind this association merit deeper investigation. Here, we used the nanopore s...
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Open AccessEvidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide
The host-microbiota co-metabolite trimethylamine N-oxide (TMAO) is linked to increased cardiovascular risk but how its circulating levels are regulated remains unclear. We applied “explainable” machine learning, ...
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Combinatorial, additive and dose-dependent drug–microbiome associations
During the transition from a healthy state to cardiometabolic disease, patients become heavily medicated, which leads to an increasingly aberrant gut microbiome and serum metabolome, and complicates biomarker ...
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Open AccessProtein supplementation during an energy-restricted diet induces visceral fat loss and gut microbiota amino acid metabolism activation: a randomized trial
Interactions between diet and gut microbiota are critical regulators of energy metabolism. The effects of fibre intake have been deeply studied but little is known about the impact of proteins. Here, we invest...
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Open AccessAuthor Correction: Revealing links between gut microbiome and its fungal community in Type 2 Diabetes Mellitus among Emirati subjects: A pilot study
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Open AccessPublisher Correction: Revealing links between gut microbiome and its fungal community in Type 2 Diabetes Mellitus among Emirati subjects: A pilot study
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessAuthor Correction: Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20412-9.
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Open AccessImidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology
Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we...
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Open AccessRevealing links between gut microbiome and its fungal community in Type 2 Diabetes Mellitus among Emirati subjects: A pilot study
Type 2 diabetes mellitus (T2DM) drastically affects the population of Middle East countries with an ever-increasing number of overweight and obese individuals. The precise links between T2DM and gut microbiome...
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Statin therapy is associated with lower prevalence of gut microbiota dysbiosis
Microbiome community ty** analyses have recently identified the Bacteroides2 (Bact2) enterotype, an intestinal microbiota configuration that is associated with systemic inflammation and has a high prevalence in...
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Open AccessHepatic stellate cell hypertrophy is associated with metabolic liver fibrosis
Hepatic fibrosis is a major consequence of chronic liver disease such as non-alcoholic steatohepatitis which is undergoing a dramatic evolution given the obesity progression worldwide, and has no treatment to ...
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Open AccessImmune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue
Adipose tissue contains a variety of immune cells, which vary in abundance and phenotype with obesity. The contribution of immune cell-derived factors to inflammatory, fibrotic and metabolic alterations in adi...
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Open AccessHypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice
Obesity is associated with local tissue hypoxia and elevated hypoxia-inducible factor 1 alpha (HIF-1α) in metabolic tissues. Prolyl hydroxylases (PHDs) play an important role in regulating HIF-α isoform stabil...
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Open AccessTM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is an increasingly common condition, strongly associated with the metabolic syndrome, that can lead to progressive hepatic fibrosis, cirrhosis and hepatic failure. Sub...
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Correction: Corrigendum: Dietary intervention impact on gut microbial gene richness
Nature 500, 585–588 (2013); doi:10.1038/nature12480 In Fig. 2 of this Letter, the units for hsCRP were incorrectly labelled as mg dl−1 instead of mg l−1. We apologize for any inconvenience this error may have ...
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Richness of human gut microbiome correlates with metabolic markers
We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We f...
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Dietary intervention impact on gut microbial gene richness
In obese and overweight individuals, diet-induced weight loss and weight-stabilization interventions improve the low microbiota gene richness and clinical phenotypes seen before intervention, but have less of ...
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Leptin regulation of bone resorption by the sympathetic nervous system and CART
Bone structure and function are maintained by bone remodelling, a balance of bone resorption by osteoclasts and bone formation by osteoblasts. New work in mice suggests that leptin, best known as a hormone reg...
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A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
The adipocyte-specific hormone leptin, the product of the obese (ob) gene,regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure1,2,3,4. Leptin acts through the leptin recept...
