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Article
Open AccessThe Swedish Cervical Screening Cohort
The Cervical Screening Cohort enrols women screened for human papillomavirus (HPV) and cervical abnormalities within the capital region of Sweden from the organised screening program and the non-organised test...
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Article
Open AccessCervical cancer screening using DNA methylation triage in a real-world population
Cervical cancer (CC) screening in women comprises human papillomavirus (HPV) testing followed by cytology triage of positive cases. Drawbacks, including cytology’s low reproducibility and requirement for short...
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Article
Low-dose aspirin use and risk of ovarian cancer: a combined analysis from two nationwide studies in Denmark and Sweden
Studies on association between low-dose aspirin use and ovarian cancer risk were mostly based on self-reported medication use and few had large enough sample size to investigate the potential modification effe...
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Article
Open AccessDNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test
Cervical screening using primary human papilloma virus (HPV) testing and cytology is being implemented in several countries. Cytology as triage for colposcopy referral suffers from several shortcomings. HPV te...
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Open AccessThe WID-CIN test identifies women with, and at risk of, cervical intraepithelial neoplasia grade 3 and invasive cervical cancer
Cervical screening is transitioning from primary cytology to primary human papillomavirus (HPV) testing. HPV testing is highly sensitive but there is currently no high-specificity triage method for colposcopy ...
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Open AccessThe WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples
Genetic and non-genetic factors contribute to breast cancer development. An epigenome-based signature capturing these components in easily accessible samples could identify women at risk. Here, we analyse the ...
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Open AccessComparison of DNA and RNA sequencing of total nucleic acids from human cervix for metagenomics
Although metagenomics and metatranscriptomics are commonly used to identify bacteria and viruses in human samples, few studies directly compare these strategies. We wished to compare DNA and RNA sequencing of ...
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Article
Open AccessDeep sequencing detects human papillomavirus (HPV) in cervical cancers negative for HPV by PCR
Human papillomavirus (HPV) is a necessary cause of cervical cancer, although some invasive cervical cancers may test negative by HPV PCR. We previously requested all invasive cervical cancers in Sweden during ...
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Open AccessClinical validation of full genoty** CLART® HPV4S assay on SurePath and ThinPrep collected screening samples according to the international guidelines for human papillomavirus test requirements for cervical screening
To ensure the highest quality of human papillomavirus (HPV) testing in primary cervical cancer screening, novel HPV assays must be evaluated in accordance with the international guidelines. Furthermore, HPV as...
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Open AccessHuman papillomavirus type 16 genomic variation in women with subsequent in situ or invasive cervical cancer: prospective population-based study
HPV genomic variation may be involved in viral carcinogenesis.
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Open AccessNationwide comprehensive human papillomavirus (HPV) genoty** of invasive cervical cancer
The Swedish National Cervical Screening Registry collects and evaluates comprehensive, nationwide health data to optimise organised cervical cancer prevention. Since all cervical cancer specimens are saved in ...
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Article
Epigenome-based cancer risk prediction: rationale, opportunities and challenges
Epigenetic misprogramming is an essential component of cancer development.
DNA methylation-based risk-predi...
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Open AccessSexually transmitted infections after bereavement – a population-based cohort study
Loss of a loved one has consistently been associated with various health risks. Little is however known about its relation to sexually transmitted infections (STIs).
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Open AccessIncidence of herpes zoster and associated events including stroke—a population-based cohort study
More detailed understanding of herpes zoster (HZ) is called for in the context of an increasing observed frequency of disease, and ongoing discussions regarding potential consequences of the disease. Thus, pop...
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Article
Loss of a parent and the risk of cancer in early life: a nationwide cohort study
While early-life exposure to stress has been associated with subsequent psychiatric and cardiovascular morbidity, little is known regarding its potential role in cancer development. We hypothesized that severe...
