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  1. Article

    Open Access

    Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia

    KMT2A-rearranged infant ALL is an aggressive childhood leukemia with poor prognosis. Here, we investigated the developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia (B-ALL) using bulk...

    Eleonora Khabirova, Laura Jardine, Tim H. H. Coorens, Simone Webb… in Nature Medicine (2022)

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  2. Article

    Open Access

    Transcriptional signals of transformation in human cancer

    As normal cells transform into cancers, their cell state changes, which may drive cancer cells into a stem-like or more primordial, foetal, or embryonic cell state. The transcriptomic profile of this final sta...

    Gerda Kildisiute, Maria Kalyva, Rasa Elmentaite, Stijn van Dongen… in Genome Medicine (2024)

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