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  1. Article

    Open Access

    The regulation and pharmacological modulation of immune complex induced type III IFN production by plasmacytoid dendritic cells

    Patients with systemic lupus erythematosus (SLE) have an ongoing interferon (IFN) production due to an activation of plasmacytoid dendritic cells (pDCs), which can be triggered to type I IFN synthesis by RNA c...

    Karin Hjorton, Niklas Hagberg, Pascal Pucholt in Arthritis Research & Therapy (2020)

  2. Article

    Open Access

    Measurement of hydroxychloroquine in blood from SLE patients using LC-HRMS—evaluation of whole blood, plasma, and serum as sample matrices

    Hydroxychloroquine (HCQ) is the standard of care in the treatment of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and other inflammatory rheumatic diseases and potentially for the treatment i...

    Henrik Carlsson, Karin Hjorton, Sandy Abujrais in Arthritis Research & Therapy (2020)

  3. Article

    Open Access

    Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor

    In systemic lupus erythematosus (SLE), immune complexes (ICs) containing self-derived nucleic acids trigger the synthesis of proinflammatory cytokines by immune cells. We asked how an interleukin (IL)-1 recept...

    Karin Hjorton, Niklas Hagberg, Elisabeth Israelsson in Arthritis Research & Therapy (2018)