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Open AccessA high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS)
Cell state-specific promoters constitute essential tools for basic research and biotechnology because they activate gene expression only under certain biological conditions. Synthetic Promoters with Enhanced C...
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Open AccessA new role of hindbrain boundaries as pools of neural stem/progenitor cells regulated by Sox2
Compartment boundaries are an essential developmental mechanism throughout evolution, designated to act as organizing centers and to regulate and localize differently fated cells. The hindbrain serves as a fas...
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ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation
The murine neonatal heart can regenerate after injury through cardiomyocyte (CM) proliferation, although this capacity markedly diminishes after the first week of life. Neuregulin-1 (NRG1) administration has b...
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Multiphase contrast-enhanced helical CT of liver metastases from renal cell carcinoma
The aim of this study was to evaluate whether in patients with metastatic renal cell carcinoma (RCC) multiphase liver studies would improve detection of metastatic liver disease. Forty-six consecutive patients...
