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    Generating knockout rats by transposon mutagenesis in spermatogonial stem cells

    Cultured rat spermatogonia, genetically modified via a transposon-based gene trap, are inserted into the testes of sterile rats and give rise to mutant progeny with many different genotypes.

    Zsuzsanna Izsvák, Janine Fröhlich, Ivana Grabundzija, James R Shirley… in Nature Methods (2010)