10 Result(s)
within
Karen Bush
Life Sciences
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Article
Critical analysis of antibacterial agents in clinical development
The antibacterial agents currently in clinical development are predominantly derivatives of well-established antibiotic classes and were selected to address the class-specific resistance mechanisms and determi...
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Article
Author Correction: Interplay between β-lactamases and new β-lactamase inhibitors
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Publisher Correction: Interplay between β-lactamases and new β-lactamase inhibitors
In figure 1 of the above article, the structure of ETX2514 was missing a double bond and methyl group. This has now been corrected in the PDF and online. The publisher apologizes to the authors and to the read...
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Article
Interplay between β-lactamases and new β-lactamase inhibitors
Resistance to β-lactam antibiotics in Gram-negative bacteria is commonly associated with production of β-lactamases, including extended-spectrum β-lactamases (ESBLs) and carbapenemases belonging to different m...
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Article
In vitro susceptibility of β-lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE) to eravacycline
Eravacycline is a novel, fully synthetic fluorocycline antibiotic of the tetracycline class being developed for the treatment of complicated urinary tract infections and complicated intra-abdominal infections....
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Article
Tackling antibiotic resistance
The increasing levels of antibiotic resistance observed in clinical isolates, coupled with a lack of new drugs coming through the development pipeline, make the problem of antibiotic resistance a global crisis...
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Article
Inhibition of metallo-β-lactamases by pyridine monothiocarboxylic acid analogs
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Article
Preparation of Erythromycin Analogs Having Functional Groups at C-15
Chemobiosynthesis has been used to prepare analogs of erythromycins having unique functional groups at the 15-position. Using diketide thioester feeding to genetically engineered Streptomyces coelicolor, analogs ...
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Article
15-Amido Erythromycins: Synthesis and in Vitro Activity of a New Class of Macrolide Antibiotics
An array of 15-amido substituted erythromycin A compounds was synthesized using a chemobiosynthesis approach. It was found that while the in vitro antibacterial activities of aryl amides were inferior to erythrom...
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Article
Activity of sulfa drugs and dihydrofolate reductase inhibitors againstCandida albicans
Growth ofCandida albicans can be inhibited by sulfa drugs which prevent biosynthesis of folic acid. The dihydrofolate reductase (E.C. 1.5.1.3) inhibitors aminopterin and methotrexate also exhibit anticandidal act...
