Skip to main content

12 Result(s)

within Kangdong Liu Remove this filter Apoptosis Remove this filter Cell Biology Remove this filter

and

  1. No Access

    Article

    PGC-1α promotes colorectal carcinoma metastasis through regulating ABCA1 transcription

    Colorectal cancer (CRC) is a highly aggressive cancer in which metastasis plays a key role. However, the mechanisms underlying metastasis have not been fully elucidated. Peroxisome proliferator-activated recep...

    Wei Chen, Qiushuang Zhang, **aoshuo Dai, **nhuan Chen, Chengjuan Zhang… in Oncogene (2023)

  2. No Access

    Article

    Diosmetin suppresses the progression of ESCC by CDK2/Rb/E2F2/RRM2 pathway and synergies with cisplatin

    Cisplatin (CDDP) is the first-line drug in the clinical treatment of esophageal squamous cell carcinoma (ESCC), which has severe nephrotoxicity. Diosmetin (DIOS) can protect kidney from oxidative damage, howev...

    Yihuan Chen, **aoshuo Dai, Wei Chen, Yan Qiao, Ruihua Bai, **aoxuan Duan… in Oncogene (2023)

  3. No Access

    Article

    New perspectives for targeting therapy in ALK-positive human cancers

    Anaplastic lymphoma kinase (ALK) is a member of the insulin receptor protein-tyrosine kinase superfamily and was first discovered in anaplastic large-cell lymphoma (ALCL). ALK alterations, including fusions, o...

    Simin Zhao, Jian Li, Qingxin **a, Kangdong Liu, Zigang Dong in Oncogene (2023)

  4. Article

    Open Access

    Vortioxetine hydrobromide inhibits the growth of gastric cancer cells in vivo and in vitro by targeting JAK2 and SRC

    Gastric cancer is the fourth leading cause of cancer deaths worldwide. Most patients are diagnosed in the advanced stage. Inadequate therapeutic strategies and the high recurrence rate lead to the poor 5-year ...

    Mingzhu Li, Lina Duan, Wenjie Wu, Wen**g Li, Lili Zhao, Ang Li, Xuebo Lu… in Oncogenesis (2023)

    Download PDF (4216 KB) View Article

  5. No Access

    Article

    Repurposed pizotifen malate targeting NRF2 exhibits anti-tumor activity through inducing ferroptosis in esophageal squamous cell carcinoma

    Targeted therapy attempts are needed to enhance esophageal squamous cell carcinoma (ESCC) patients’ overall survival and satisfaction of life. Nuclear factor erythroid 2-related factor 2 (NRF2), as a high-conf...

    **nyu He, Yubing Zhou, Wen**g Chen, **aokun Zhao, Lina Duan, Hao Zhou… in Oncogene (2023)

  6. No Access

    Article

    A novel lncRNA MTAR1 promotes cancer development through IGF2BPs mediated post-transcriptional regulation of c-MYC

    Abnormal translation of the MYC proto-oncogene is a hallmark of the initiation and maintenance of tumorigenesis. However, the molecular mechanism underlying increased MYC protein levels in certain cancer types...

    Yunfeng Gao, Ming Jiang, Fangqin Guo, Xuejiao Liu, Qi Zhang, Sen Yang… in Oncogene (2022)

  7. No Access

    Article

    BRD4 drives esophageal squamous cell carcinoma growth by promoting RCC2 expression

    The low survival rate of esophageal squamous cell carcinoma patients is primarily attributed to technical limitations and a lack of insight regarding the molecular mechanisms contributing to its progression. A...

    Qiong Wu, Fangfang Liu, Mengmeng Ge, Kyle Vaughn Laster, Lixiao Wei, Ruijuan Du… in Oncogene (2022)

  8. No Access

    Article

    CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating β-catenin/ MEK-ERK signaling pathway

    Colorectal cancer (CRC) is the third most diagnosed cancer and the second leading cause of cancer-related deaths. However, there are few effective therapeutic targets for CRC patients. Here, we found that CDK1...

    Chuntian Huang, Ruijuan Du, Xuechao Jia, Kangdong Liu… in Cell Death & Differentiation (2022)

  9. Article

    Open Access

    Cloperastine inhibits esophageal squamous cell carcinoma proliferation in vivo and in vitro by suppressing mitochondrial oxidative phosphorylation

    Esophageal squamous cell carcinoma (ESCC) is a major type of esophageal cancer. The prognosis of patients with ESCC remains poor because of the high morbidity and mortality of the disease. One strategy for dru...

    Bo Li, Yin Yu, Yanan Jiang, Lili Zhao, Ang Li, Mingzhu Li… in Cell Death Discovery (2021)

    Download PDF (6023 KB) View Article

  10. No Access

    Article

    Periplogenin suppresses the growth of esophageal squamous cell carcinoma in vitro and in vivo by targeting STAT3

    The mortality rate of esophageal squamous cell carcinoma (ESCC) is higher than that of other cancers worldwide owing to a lack of therapeutic targets and related drugs. This study aimed to find new drugs by ta...

    Yamei Hu, Fangfang Liu, Xuechao Jia, Penglei Wang, Tingxuan Gu, Hui Liu… in Oncogene (2021)

  11. No Access

    Article

    Discovery of a novel dual-target inhibitor against RSK1 and MSK2 to suppress growth of human colon cancer

    Colon cancer is the most aggressive tumor in both men and women globally. As many the chemotherapeutic regimens have adverse side effects and contribute to the resistance and recurrence, therefore, finding nov...

    Guoguo **, Mingyang Yan, Kangdong Liu, Ke Yao, Hanyong Chen, Chengjuan Zhang… in Oncogene (2020)

  12. No Access

    Article

    SDCBP/MDA-9/syntenin phosphorylation by AURKA promotes esophageal squamous cell carcinoma progression through the EGFR-PI3K-Akt signaling pathway

    SDCBP is an adapter protein containing two tandem PDZ domains mediating cell adhesion. The role and underlying molecular mechanism of SDCBP in ESCC remain obscure. Here, we report that SDCBP is frequently over...

    Ruijuan Du, Chuntian Huang, Hanyong Chen, Kangdong Liu, Pu **ang, Ning Yao… in Oncogene (2020)