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  1. Article

    Open Access

    Clinical benefit of treatment after trastuzumab emtansine for HER2-positive metastatic breast cancer: a real-world multi-centre cohort study in Japan (WJOG12519B)

    Trastuzumab emtansine (T-DM1) treatment for human epidermal growth factor receptor-2 (HER2)-positive metastatic breast cancer after taxane with trastuzumab and pertuzumab is standard therapy. However, treatmen...

    Takamichi Yokoe, Sasagu Kurozumi, Kazuki Nozawa, Yukinori Ozaki… in Breast Cancer (2021)

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  2. Article

    Open Access

    Impact of clinical targeted sequencing on endocrine responsiveness in estrogen receptor-positive, HER2-negative metastatic breast cancer

    Clinical targeted sequencing allows for the selection of patients expected to have a better treatment response, and reveals mechanisms of resistance to molecular targeted therapies based on actionable gene mut...

    Kanako Hagio, Toraji Amano, Hideyuki Hayashi, Takashi Takeshita… in Scientific Reports (2021)

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  3. No Access

    Article

    Tamoxifen withdrawal in women with progressive metastatic breast cancer: a case series of six patients

    Estrogen receptor (ER)-positive metastatic breast cancers after a period of response to tamoxifen develop resistance, and the disease progresses clinically. Domination of partial agonistic activity of tamoxife...

    Kanako Hagio, Motoi Baba, Naoko Ishida… in International Cancer Conference Journal (2018)