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  1. Article

    Open Access

    Spinal 5-HT3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade

    It has been recently recognized that the descending serotonin (5-HT) system from the rostral ventromedial medulla (RVM) in the brainstem and the 5-HT3 receptor subtype in the spinal dorsal horn are involved in en...

    Wei Guo, Kan Miyoshi, Ronald Dubner, Ming Gu, Man Li, Jian Liu… in Molecular Pain (2014)

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    Article

    Changes in the rewarding effects induced by tramadol and its active metabolite M1 after sciatic nerve injury in mice

    The present study was designed to investigate the rewarding effects induced by tramadol and its active metabolite O-desmethyltramadol (M1) under a neuropathic pain-like state.

    Atsushi Nakamura, Minoru Narita, Kan Miyoshi, Keiko Shindo… in Psychopharmacology (2008)

  3. Article

    Comparative Pharmacological Profiles of Morphine and Oxycodone under a Neuropathic Pain-Like State in Mice: Evidence for Less Sensitivity to Morphine

    The present study was undertaken to investigate pharmacological actions induced by morphine and oxycodone under a neuropathic pain-like state. In the μ-opioid receptor (MOR) binding study and G-protein activation...

    Minoru Narita, Atsushi Nakamura, Masahiko Ozaki, Satoshi Imai… in Neuropsychopharmacology (2008)

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  4. Article

    Chronic Pain Induces Anxiety with Concomitant Changes in Opioidergic Function in the Amygdala

    Clinically, it has been reported that chronic pain induces depression, anxiety, and reduced quality of life. The endogenous opioid system has been implicated in nociception, anxiety, and stress. The present st...

    Minoru Narita, Chihiro Kaneko, Kan Miyoshi, Yasuyuki Nagumo… in Neuropsychopharmacology (2006)

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