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Article
Evidence for RA-dependent meiosis onset in a turtle embryo
Meiotic entry is one of the earliest sex determination events of the germ cell in higher vertebrates. Although advances in meiosis onset have been achieved in mammals, birds and fish, how this process function...
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Chapter and Conference Paper
Group-Agent Reinforcement Learning
It can largely benefit the reinforcement learning (RL) process of each agent if multiple geographically distributed agents perform their separate RL tasks cooperatively. Different from multi-agent reinforcemen...
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Article
Sensitive detection of SARS-CoV-2 on paper
An assay leveraging strand-displacement reactions and enzymatic amplification for the recognition of viral RNA and implemented on origami paper allows for the fast colorimetric detection of SARS-CoV-2 variants...
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Article
PM2.5-Induced Programmed Myocardial Cell Death via mPTP Opening Results in Deteriorated Cardiac Function in HFpEF Mice
PM2.5 exposure can induce or exacerbate heart failure and is associated with an increased risk of heart failure hospitalization and mortality; however, the underlying mechanisms remain unclear. This study focu...
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Article
Open AccessNovel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern, including Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), and Omicron (B.1.1.529) has aroused...
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Article
Open AccessMulti-arm RNA junctions encoding molecular logic unconstrained by input sequence for versatile cell-free diagnostics
Applications of RNA-based molecular logic have been hampered by sequence constraints imposed on the input and output of the circuits. Here we show that the sequence constraints can be substantially reduced by ...
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Chapter and Conference Paper
SchedP: I/O-aware Job Scheduling in Large-Scale Production HPC Systems
Job schedulers on High Performance Computing systems can serve more purposes than just maximising computing resource utilisation if they are equipped with more awareness on other aspects of the system. In this...
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Protocol
Computational Design of RNA Toehold-Mediated Translation Activators
Translation activators are an important class of riboregulators that respond to nucleic acid signals by activating gene expression. Toehold switches and single-nucleotide-specific programmable riboregulators (SNI...
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Protocol
Detection of Norovirus Using Paper-Based Cell-Free Systems
Norovirus infections are the leading cause of foodborne illness and human gastroenteritis, afflicting hundreds of millions of people each year. Molecular assays with the capacity to detect norovirus without ex...
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Article
Predictable control of RNA lifetime using engineered degradation-tuning RNAs
The ability to tune RNA and gene expression dynamics is greatly needed for biotechnological applications. Native RNA stabilizers or engineered 5′ stability hairpins have been used to regulate transcript half-l...
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Chapter and Conference Paper
AdverseGen: A Practical Tool for Generating Adversarial Examples to Deep Neural Networks Using Black-Box Approaches
Deep neural networks are fragile as they are easily fooled by inputs with deliberate perturbations, which are key concerns in image security issues. Given a trained neural network, we are always curious about ...
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Article
Open AccessSignature-tagged mutagenesis screening revealed a novel smooth-to-rough transition determinant of Salmonella enterica serovar Enteritidis
Salmonella enterica serovar Enteritidis (S. Enteritidis) has emerged as one of the most important food-borne pathogens for humans. Lipopolysaccharide (LPS), as a component of the outer...
