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Article
Open AccessA neural mechanism for conserved value computations integrating information and rewards
Behavioral and economic theory dictate that we decide between options based on their values. However, humans and animals eagerly seek information about uncertain future rewards, even when this does not provide...
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Article
Discovering covalent inhibitors of protein–protein interactions from trillions of sulfur(VI) fluoride exchange-modified oligonucleotides
Molecules that covalently engage target proteins are widely used as activity-based probes and covalent drugs. The performance of these covalent inhibitors is, however, often compromised by the paradox of effic...
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Chapter and Conference Paper
Approximate k-Nearest Neighbor Query over Spatial Data Federation
Approximate nearest neighbor query is a fundamental spatial query widely applied in many real-world applications. In the big data era, there is an increasing demand to scale these queries over a spatial data f...
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Article
Open AccessThe targets of aspirin in bladder cancer: bioinformatics analysis
The anti-carcinogenic properties of aspirin have been observed in some solid tumors. However, the molecular mechanism of therapeutic effects of aspirin on bladder cancer is still indistinct. We introduced a bi...
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Article
Open AccessThe TAS Test project: a prospective longitudinal validation of new online motor-cognitive tests to detect preclinical Alzheimer’s disease and estimate 5-year risks of cognitive decline and dementia
The worldwide prevalence of dementia is rapidly rising. Alzheimer’s disease (AD), accounts for 70% of cases and has a 10–20-year preclinical period, when brain pathology covertly progresses before cognitive sy...
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Article
A primate temporal cortex–zona incerta pathway for novelty seeking
Primates interact with the world by exploring visual objects; they seek opportunities to view novel objects even when these have no extrinsic reward value. How the brain controls this novelty seeking is unknow...
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Article
Resonance assignments of bacteriophage T4 Y04L protein
Phage study draws more attention recently as the bacterial antibiotic resistances become a major threat for global health. Bacteriophage T4 is one of the most studied the phages and the representative of Teven...
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Article
Open AccessA neural network for information seeking
Humans and other animals often show a strong desire to know the uncertain rewards their future has in store, even when they cannot use this information to influence the outcome. However, it is unknown how the ...
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Article
Open AccessFine-tuning the expression of target genes using a DDI2 promoter gene switch in budding yeast
Tuned gene expression is crucial to the proper growth and response to the environmental changes of an organism. To enable tunable gene expression as designed is desirable in both scientific research and indust...
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Article
Resonance assignments of sigma factor S binding protein Crl from Escherichia coli
During bacterial transcription, sigma (σ) factors reversibly bind to RNA polymerase (RNAP) and recognize specific promoter sequences to initiate the process. While different sigma factors are utilized under di...
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Article
Open Accessrs1760944 Polymorphism in the APE1 Region is Associated with Risk and Prognosis of Osteosarcoma in the Chinese Han Population
The effects of single nucleotide polymorphisms (SNPs) at APE1 have been investigated in several types of cancer. However, no reports of the association of APE1 polymorphisms with osteosarcoma (OS) have been pu...
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Article
Open AccessEffector T helper cell populations are elevated in the bone marrow of rheumatoid arthritis patients and correlate with disease severity
This study is to investigate the frequencies of T-helper (Th)22, Th17 and Th1 cells and the levels of related cytokines in subchondral bone marrow in patients with rheumatoid arthritis (RA). Bone marrow and pe...
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Article
Primary study on the lesions and specific proteins in BEAS-2B cells induced with the 2009 A (H1N1) influenza virus
In order to investigate the lesions and proteins with differential expression in cells infected with the 2009 A (H1N1) virus and to determine the specific proteins involved in cell damage, the present study ha...
