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    Chapter

    History, Chemistry and Antibacterial Spectrum

    Polymyxins are naturally occurring cyclic lipopeptides that were discovered more than 60 years ago. They have a narrow antibacterial spectrum, which is mainly against Gram-negative pathogens. The dry antibioti...

    Tony Velkov, Philip E. Thompson… in Polymyxin Antibiotics: From Laboratory Ben… (2019)

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    Chapter

    Discovery of Novel Polymyxin-Like Antibiotics

    The antimicrobial lipopeptides polymyxin B and colistin (polymyxin E) are used as a ‘last-line’ therapy for infections caused by multidrug-resistant (MDR) Gram-negative pathogens. However, their effective use ...

    Tony Velkov, Kade D. Roberts in Polymyxin Antibiotics: From Laboratory Bench to Bedside (2019)