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Article
Open AccessSex Moderates the Association between Frailty and Mild Behavioral Impairment
Frailty has been associated with cognitive markers of dementia but its relationship with behavioral markers of dementia are poorly understood.
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Reference Work Entry In depth
Cognition and Frailty
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Article
An MDS-specific frailty index based on cumulative deficits adds independent prognostic information to clinical prognostic scoring
The frailty index (FI) is based on the principle that the more deficits an individual has, the greater their risk of adverse outcomes. It is expressed as a ratio of the number of deficits present to the total ...
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Living Reference Work Entry In depth
Cognition and Frailty
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Article
Open AccessMoving Towards Common Data Elements and Core Outcome Measures in Frailty Research
With aging populations around the world, frailty is becoming more prevalent increasing the need for health systems and social systems to deliver optimal evidence based care. However, in spite of the growing nu...
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Article
Proceedings of the Canadian Frailty Network Workshop: Identifying Biomarkers of Frailty to Support Frailty Risk Assessment, Diagnosis and Prognosis. Toronto, January 15, 2018
The Canadian Frailty Network (CFN), a pan-Canadian not-for-profit organization funded by the Government of Canada through the Networks of Centres of Excellence Program, is dedicated to improving the care of ol...
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Article
Can a Prebiotic Formulation Reduce Frailty Levels in Older People?
The purpose of this study was to examine whether a prebiotic formulation reduces frailty index (FI) levels in older people.
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Article
Social and Societal Implications of Frailty, Including Impact on Canadian Healthcare Systems
Frailty has many social and societal implications. Social circumstances are key both as contributors to frail older adults’ health outcomes and as practical facilitators or barriers to intervention and support...
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Article
Aging, frailty and complex networks
When people age their mortality rate increases exponentially, following Gompertz’s law. Even so, individuals do not die from old age. Instead, they accumulate age-related illnesses and conditions and so become...
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Article
Open AccessA Frailty Index Based On Deficit Accumulation Quantifies Mortality Risk in Humans and in Mice
Although many common diseases occur mostly in old age, the impact of ageing itself on disease risk and expression often goes unevaluated. To consider the impact of ageing requires some useful means of measurin...
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Article
A Frailty Index predicts 10-year fracture risk in adults age 25 years and older: results from the Canadian Multicentre Osteoporosis Study (CaMos)
We created a 30-item Frailty Index in the Canadian Multicentre Osteoporosis Study. A Frailty Index is a sensitive measure that can quantify fracture risk according to degree of frailty. Our results indicated t...
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Article
Promoting access to innovation for frail old persons
Frailty tends to be considered as a major risk for adverse outcomes in older persons, but some important aspects remain matter of debate.
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Article
Transitions in cognitive status in relation to frailty in older adults: A Comparison of three frailty measures
Cognitive decline is related to frailty. Frailty can be operationalized in different ways, which have an unknown impact on the estimation of risk. Here, we compared 3 frailty measures in relation to cognitive ...
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Article
Comparison of two frailty measures in the Conselice Study of Brain Ageing
Uncertainty about the definition of frailty is reflected by the development of many ways to identify frail people. We aimed to compare the validity of two frailty measures in participants of the Conselice Stud...
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Article
Effect of smoking on the accumulation of deficits, frailty and survival in older adults: A secondary analysis from the Canadian study of health and aging
Smoking has adverse effects on a variety of organ systems but little is known about the relationship between smoking and frailty. We aimed to investigate differences in health status between smoking and non sm...
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Article
Gait and posture impairment, parkinsonism and cognitive decline in older people
Our objective was to examine the frequency of gait and posture impairment and parkinsonism in 3 waves of the Canadians Study of Health and Aging (CSHA) and to determine their relationship to the development of...
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Chapter and Conference Paper
Research criteria for subcortical vascular dementia in clinical trials
Vascular dementia (VaD) incorporate different vascular mechanisms and changes in the brain, and have different causes and clinical manifestations. Variation in defining the cognitive syndrome, in vascular etio...
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Article
Clinical practice guidelines for screening and monitoring male patients receiving testosterone supplementation therapy
