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Article
Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX
A large international meta-analysis using primary data from 64 cohorts has quantified the increased risk of fracture associated with a previous history of fracture for future use in FRAX.
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Article
Open AccessAre higher antidepressant plasma concentrations associated with fall risk in older antidepressant users?
To explore the association between antidepressant plasma concentrations and fall risk in older users.
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Article
Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan
We describe the collection of cohorts together with the analysis plan for an update of the fracture risk prediction tool FRAX with respect to current and novel risk factors. The resource comprises 2,138,428 p...
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Reply to “Screening for high fracture risk”
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Open AccessFracture prevention by screening for high fracture risk: a systematic review and meta-analysis
This systematic review and meta-analysis showed a significant reduction of (major) osteoporotic fractures and hip fractures after screening using fracture risk assessment and bone densitometry compared with us...
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Open AccessPrediction of insufficient serum vitamin D status in older women: a validated model
We developed an externally validated simple prediction model to predict serum 25(OH)D levels < 30, < 40, < 50 and 60 nmol/L in older women with risk factors for fractures. The benefit of the model reduces when...
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Vitamin B12 intake and related biomarkers: Associations in a Dutch elderly population
Vitamin B12 status is measured by four plasma/serum biomarkers: total vitamin B12 (total B12), holotranscobalamin (holoTC), methylmalonic acid (MMA) and homocysteine (tHcy). Associations of B12 intake with hol...
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Open AccessDesign of the SALT Osteoporosis Study: a randomised pragmatic trial, to study a primary care screening and treatment program for the prevention of fractures in women aged 65 years or older
Several drugs have become available for the treatment of osteoporosis. However, screening and treatment of patients with a high fracture risk is currently not recommended in the Netherlands, because the effect...
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Open AccessLow vitamin D status is associated with more depressive symptoms in Dutch older adults
The existence of vitamin D receptors in the brain points to a possible role of vitamin D in brain function. We examined the association of vitamin D status and vitamin D-related genetic make-up with depressive...
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Article
Arterial stiffness is not associated with bone parameters in an elderly hyperhomocysteinemic population
Several studies have observed positive associations between bone disease and cardiovascular disease. A potential common pathway is hyperhomocysteinemia; however, to date, there is a lack of data regarding hype...
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Article
BMI and body fat mass is inversely associated with vitamin D levels in older individuals
To assess the association between obesity (measured by Body Mass Index (BMI) and fat percentage) and serum 25(OH)D levels in older persons.
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Article
Physical fitness, activity and hand-grip strength are not associated with arterial stiffness in older individuals
Whereas evidence exists about the benefits of intensive exercise on cardiovascular outcomes in older adults, data are lacking regarding long-term effects of physical fitness and physical activity on cardiovasc...
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Article
The Association Between Vitamin D Status and Parameters for Bone Density and Quality is Modified by Body Mass Index
The association of vitamin D status with bone mineral density (BMD) and Quantitative Ultrasound measurements (QUS) has been inconsistent in previous studies, probably caused by moderating effects. This study e...
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Homocysteine and the methylenetetrahydrofolate reductase 677C→T polymorphism in relation to muscle mass and strength, physical performance and postural sway
Elevated plasma homocysteine has been linked to reduced mobility and muscle functioning in the elderly. The relation of methylenetetrahydrofolate reductase (MTHFR) 677C→T polymorphism with these associations h...
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Article
Elevated homocysteine levels are associated with low muscle strength and functional limitations in older persons
The current study aimed to examine homocysteine in relation to different aspects of physical functioning.
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Vitamin D status is associated with physical performance: the results of three independent cohorts
This study, on the association between vitamin D status and physical performance and its decline, shows that vitamin D status is associated with physical performance in several older age groups. However, vitam...
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Cross-sectional and longitudinal association between homocysteine, vitamin B12 and physical performance in older persons
Decreases in physical performance are associated with multiple negative health outcomes. The objective of this study was to examine whether high plasma homocysteine and low serum vitamin B12 are independent ri...
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Homocysteine and the risk of nursing home admission and mortality in older persons
This study aimed to investigate whether higher homocysteine and lower vitamin B12 concentrations increase the risk of future nursing home (NH) admission and all-cause mortality in independently living older pe...
