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Article
Buchbesprechungen
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Chapter and Conference Paper
A Na+,K+-ATPase inhibitor isolated from pig kidney
Pig kidney alcoholic extracts contain various substances which cross-react with antibodies for cardiac glycosides. Further fractions were found which inhibited Na+,K+-ATPase activity, displaced 3H-ouabain binding...
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Chapter
Introduction and Remarks on the History of Cardiac Glycosides
If cardiac glycosides were to be introduced into therapy today the state authorities would most likely refuse permission, due to the extreme toxicity and narrow therapeutic range of these compounds. Today, how...
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Chapter
Effects of Cardiac Glycosides on Skeletal Muscle
Cardiac glycosides, in therapeutic concentrations, are considered to influence the force of contraction of the heart, not only during an existing insufficiency but also in normal healthy conditions. A similar ...
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Chapter
Evaluation of Cardiac Glycosides in Isolated Heart Preparations Other than Papillary Muscle
Complementary to Chap. 9, which dealt primarily with the evaluation of cardiac glycosides in isolated papillary muscle, further methods often used in the quantitative and qualitative analysis of the action of ...
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Chapter
Evaluation of Cardiac Glycosides in the Intact Animal
For many decades biologic evaluation in experimental animals was the only way of standardizing extracts from digitalis or other plants, in order to obtain guidelines for their therapeutic dosage. Subsequently,...
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Chapter
Substances Possessing Inotropic Properties Similar to Cardiac Glycosides
The positive inotropic actions of the cardiotonic steroids and their glycosides can be distinguished from those of other positive inotropic agents, such as catecholamines or xanthine derivatives (see Chap. 10 ...
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Chapter
Pharmacokinetics of Strophanthus Glycosides
Of the therapeutically useful strophanthus glycosides, only those of strophanthidin K or ouabagenin (strophanthidin G) are now used in a pure form. They are present in a variety of plants but are mainly extrac...
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Article
The positive inotropic, antiarrhythmic and Na+, K+-ATPase inhibitory effects of the isoquinoline derivative, BIIA
The effect of the isoquinoline derivative 3-benzylamino-5,6-dihydro-8,9-dimethoxy-imidazo-5,1-a-isoquinoline-hydrochloride (BIIA) were studied in the cat in situ and guinea-pig isolated heart preparations:
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Article
Influence of vanadate on electrophysiological and contractile parameters of atrial myocardium
Whereas vanadate increases isometric force of contraction in stimulated rat left atria (EC50 ∶ 36.6 μmol/l), it decreases force of contraction in guinea-pigs (EC50 ∶ 4.7 μmol/l). Action potential duration at 90 a...
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Article
Quantitative Beurteilung herzwirksamer Pharmaka durch Rechner-gesteuerte Analyse der Ventrikeldruckkurve während der isovolumetrischen Kontraktion
Left ventricular pressure (P) and its rate of increase (dP/dt) were recorded using a digital computer (Dietz Mincal 621) and ventricular pressure curves during isovolumetric contraction were analysed by an off...
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Article
Negative and positive inotropic action of vanadate on atrial and ventricular myocardium
VANADATE (vanadium in the +5 oxidation state) occurs widely in animal tissues1, and has been suggested to be the first regulatory agent of (Na+ + K+)ATPase; it inhibits ATPase preparations from kidney and red blo...
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Chapter and Conference Paper
Zur Pharmakokinetik von k-Strophanthin
Zur Kinetik der k-Strophanthine liegen bisher nur wenige, ausschließlich mit 3H-mar-kierten Verbindungen durchgeführte Untersuchungen vor. Verfahren zum radioimmu-nologischen Nachweis von k-Strophanthinen standen...
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Chapter and Conference Paper
Beschreibung der Materialeigenschaften isolierter Herzmuskelpräparate mit Hilfe eines elektrostatisch-mechanischen Modells
Die dynamischen, viskoelastischen Materialeigenschaften des Papillarmuskels der Katze werden durch ein phys.-math. Modell beschrieben. Das Modell berücksichtigt die Steifigkeit des Bindegewebes, der Aktinfilam...
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Chapter
Characterization of Cardioactive Agents using the Analysis of the Ventricular Pressure Curve during Isovolumetric Contraction
The rate of rise of ventricular pressure during contraction depends on the myocardial contractile state, the loading conditions and on autoregulation. The characterization of cardioactive agents by measuring p...
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Chapter and Conference Paper
Neue Meßmethode zur Bestimmung physikalischer Eigenschaften von isolierten Muskelpräparaten
Es wurde eine im industriellen Bereich zur Untersuchung viskoelastischer Materialien verwendete Meßmethode so modifiziert, daß der dynamische, komplexe Elastizitätsmodul (E* = E · (1 + i Δ) E Young’scher E-Mod...
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Article
Die rhythmogenese der atmung beschrieben mit hilfe des Lotka-Volterra-modells: Experimente und simulation
The aim of the present study was to simulate respiratory responses to vagal stimulation using theLotka-Volterra model, a system of two simultaneous non-linear differential equations. The experiments were carried ...
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Chapter and Conference Paper
Aussprache
Schoner und Bolte haben in ihren Referaten daraufhingewiesen, daß die Na+ + K+-ATPase der Zellmembran des Herzmuskels der wichtigste Angriffsort und Rezeptor der Digitalisglykoside ist. Die Hemmung dieses Enzyms ...
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Chapter and Conference Paper
Contraction and Relaxation of Heart Muscle as Influenced by cAMP, Isoproterenol, Glucagon, Ouabain, and Calcium
In analyzing the isometric contraction curves of isolated heart preparations, the positive inotropic effect of sympathomimetic amines is seen to be concomitant with an increase of the relaxation velocity and a...
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Article
Die kardiodepressive Wirkung des Bencyclans
In the isolated guinea pigs atria as well as in anaesthetized cats and dogs we studied the cardiovascular effects of bencyclan. The following results were found:
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