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8 Result(s)

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  1. No Access

    Article

    Antigen-presenting cell-targeted lentiviral vectors do not support the development of productive T-cell effector responses: implications for in vivo targeted vaccine delivery

    Targeting transgene expression specifically to antigen-presenting cells (APCs) has been put forward as a promising strategy to direct the immune system towards immunity. We developed the nanobody-display techn...

    C Goyvaerts, Y De Vlaeminck, D Escors, S Lienenklaus, M Keyaerts, G Raes… in Gene Therapy (2017)

  2. No Access

    Article

    Interference with PD-L1/PD-1 co-stimulation during antigen presentation enhances the multifunctionality of antigen-specific T cells

    The release of cytokines by T cells strongly defines their functional activity in vivo. The ability to produce multiple cytokines has been associated with beneficial immune responses in cancer and infectious dise...

    J J Pen, B D Keersmaecker, C Heirman, J Corthals, T Liechtenstein, D Escors… in Gene Therapy (2014)

  3. No Access

    Article

    Downregulation of Stat3 in melanoma: reprogramming the immune microenvironment as an anticancer therapeutic strategy

    Persistent activation of the transcription factor, signal transducer and activator of transcription 3 (Stat3) has been shown to mediate several oncogenic features in many types of cancers, including melanoma. ...

    P U Emeagi, S Maenhout, N Dang, C Heirman, K Thielemans, K Breckpot in Gene Therapy (2013)

  4. Article

    Open Access

    Development of the Nanobody display technology to target lentiviral vectors to antigen-presenting cells

    Lentiviral vectors (LVs) provide unique opportunities for the development of immunotherapeutic strategies, as they transduce a variety of cells in situ, including antigen-presenting cells (APCs). Engineering LVs ...

    C Goyvaerts, K De Groeve, J Dingemans, S Van Lint, L Robays, C Heirman… in Gene Therapy (2012)

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  5. No Access

    Article

    Lentiviral vectors for cancer immunotherapy: transforming infectious particles into therapeutics

    Lentiviral vectors have emerged as promising tools for both gene therapy and immunotherapy purposes. They exhibit several advantages over other viral systems in that they are less immunogenic and are capable o...

    K Breckpot, J L Aerts, K Thielemans in Gene Therapy (2007)

  6. No Access

    Article

    Induction of antigen-specific CD8+ cytotoxic T cells by dendritic cells co-electroporated with a dsRNA analogue and tumor antigen mRNA

    The maturation state of dendritic cells (DCs) is an important determinant for the initiation and regulation of adaptive immune responses. In this study, we wanted to assess whether functional activation of hum...

    A Michiels, K Breckpot, J Corthals, S Tuyaerts, A Bonehill, C Heirman… in Gene Therapy (2006)

  7. No Access

    Article

    Induction of effective therapeutic antitumor immunity by direct in vivo administration of lentiviral vectors

    Ex vivo lentivirally transduced dendritic cells (DC) have been described to induce CD8+ and CD4+ T-cell responses against various tumor-associated antigens (TAAs) in vitro and in vivo. We report here that direct ...

    M Dullaers, S Van Meirvenne, C Heirman, L Straetman, A Bonehill, J L Aerts… in Gene Therapy (2006)

  8. No Access

    Article

    Electroporation of immature and mature dendritic cells: implications for dendritic cell-based vaccines

    Until now, studies utilizing mRNA electroporation as a tool for the delivery of tumor antigens to human monocyte-derived dendritic cells (DC) have focused on DC electroporated in an immature state. Immature DC...

    A Michiels, S Tuyaerts, A Bonehill, J Corthals, K Breckpot, C Heirman… in Gene Therapy (2005)