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  1. No Access

    Article

    Phosphorylated STAT3 physically interacts with NPM and transcriptionally enhances its expression in cancer

    The signal transducer and activator of transcription 3 (STAT3) can be activated by the tyrosine kinase domain of the chimeric protein nucleophosmin/anaplastic lymphoma kinase (NPM/ALK), and has a pivotal role ...

    Z Ren, J L Aerts, J J Pen, C Heirman, K Breckpot, J De Grève in Oncogene (2015)

  2. No Access

    Article

    Interference with PD-L1/PD-1 co-stimulation during antigen presentation enhances the multifunctionality of antigen-specific T cells

    The release of cytokines by T cells strongly defines their functional activity in vivo. The ability to produce multiple cytokines has been associated with beneficial immune responses in cancer and infectious dise...

    J J Pen, B D Keersmaecker, C Heirman, J Corthals, T Liechtenstein, D Escors… in Gene Therapy (2014)