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  1. Article

    Open Access

    MicroRNA-149 targets GIT1 to suppress integrin signaling and breast cancer metastasis

    Metastasis is the predominant cause of death in breast cancer patients. Several lines of evidence have shown that microRNAs (miRs) can have an important role in cancer metastasis. Using isogenic pairs of low a...

    S-H Chan, W-C Huang, J-W Chang, K-J Chang, W-H Kuo, M-Y Wang, K-Y Lin, Y-H Uen… in Oncogene (2014)

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  2. No Access

    Article

    Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-κB-mediated antiapoptotic pathway

    Gain of function of membrane receptor was a good strategy exploited by cancer cells to benefit own growth and survival. Overexpression of HER2 has been found to serve as a target for develo** trastuzumab to ...

    C-K Huang, C-Y Yang, Y-M Jeng, C-L Chen, H-H Wu, Y-C Chang, C Ma, W-H Kuo… in Oncogene (2014)

  3. No Access

    Article

    miR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1

    MicroRNAs (miRNAs) are involved in tumorigenecity by regulating specific oncogenes and tumor suppressor genes, and their roles in breast cancer stem cells (BCSCs) are becoming apparent. Distinct from the CD44+/CD...

    W W Hwang-Verslues, P-H Chang, P-C Wei, C-Y Yang, C-K Huang, W-H Kuo, J-Y Shew… in Oncogene (2011)

  4. Article

    Open Access

    Cumulative survival in early-onset unilateral and bilateral breast cancer: an analysis of 1907 Taiwanese women

    As the epidemiological pattern of breast cancer in modernising Asian countries differs greatly from that in Western countries, it is worthwhile to investigate the long-term prognoses of unilateral and bilatera...

    W-H Kuo, A M-F Yen, P-H Lee, K-M Chen, J Wang, K-J Chang… in British Journal of Cancer (2009)

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  5. No Access

    Article

    Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial–mesenchymal transition

    Metaplastic carcinoma of the breast (MCB) is a poorly understood subtype of breast cancer. It is generally characterized by the coexistence of ductal carcinomatous and transdifferentiated sarcomatous component...

    H C Lien, Y H Hsiao, Y S Lin, Y T Yao, H F Juan, W H Kuo, Mien-Chie Hung… in Oncogene (2007)

  6. Article

    Open Access

    Cytochrome P4501A1 polymorphism as a susceptibility factor for breast cancer in postmenopausal Chinese women in Taiwan

    The incidence of breast cancer has been greatly increasing in Taiwan over the past two decades. Since cytochrome P4501A1 (CYP1A1) is involved in the metabolism of environmental carcinogens or oestrogen, we hyp...

    C-S Huang, C-Y Shen, K-J Chang, S-M Hsu, H-D Chern in British Journal of Cancer (1999)

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