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Article
Standards of Fluid Biomarker Collection and Pre-analytical Processes in Humans and Mice: Recommendations by the Ataxia Global Initiative Working Group on Biomarkers
The Ataxia Global Initiative (AGI) aims to serve as a platform to facilitate clinical trial readiness for the hereditary ataxias. Clinical trials for these diseases have been hampered by the lack of objective ...
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Article
Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation
Common genetic risk for neuropsychiatric disorders is enriched in regulatory elements active during cortical neurogenesis. However, it remains poorly understood as to how these variants influence gene regulati...
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Article
Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA
Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by a mutation or deletion of the maternally inherited UBE3A allele. In neurons, the paternally inherited UBE3A allele is silenced in cis by a ...
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Article
Open AccessHigh-throughput screening and classification of chemicals and their effects on neuronal gene expression using RASL-seq
We previously used RNA-seq to identify chemicals whose effects on neuronal gene expression mimicked transcriptional signatures of autism, aging, and neurodegeneration. However, this approach was costly and tim...
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Article
Open AccessDifferential expression of conserved and novel microRNAs during tail regeneration in the lizard Anolis carolinensis
Lizards are evolutionarily the most closely related vertebrates to humans that can lose and regrow an entire appendage. Regeneration in lizards involves differential expression of hundreds of genes that regula...
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Article
Open AccessA human 3′UTR clone collection to study post-transcriptional gene regulation
3′untranslated regions (3′UTRs) are poorly understood portions of eukaryotic mRNAs essential for post-transcriptional gene regulation. Sequence elements in 3′UTRs can be target sites for regulatory molecules s...
