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Open AccessClinical-neuroimaging-pathological relationship analysis of adult onset Neuronal Intranuclear Inclusion Disease (NIID)
Neuronal Intranuclear Inclusion Disease (NIID) is a degenerative disease with heterogeneous clinical manifestations. We aim to analysis the relationship between clinical manifestations, neuroimaging and skin p...
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Expression and methylation status of MMR and MGMT in well-differentiated pancreatic neuroendocrine tumors and potential clinical applications
Recent studies claim that immune checkpoint inhibitors are effective in defective mismatch repair (dMMR) cancers. This raises the question of whether similar therapies are effective in PanNETs (pancreatic neur...
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Open AccessPrognostic significance of different molecular ty** methods and immune status based on RNA sequencing in HR-positive and HER2-negative early-stage breast cancer
This study was conducted to evaluate the prognostic significance of different molecular ty** methods and immune status based on RNA sequencing (RNA-seq) in hormone receptor (HR)-positive and human epidermal ...
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Open AccessDNA Mismatch Repair Deficiency Detection in Colorectal Cancer by a New Microsatellite Instability Analysis System
Although microsatellite instability (MSI) is most commonly detected in colorectal cancer (CRC), improvement in MSI analysis method can always help us better assessing MSI phenotypes and gaining useful informat...
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Open AccessTonghua Liu: A life dedicated to clinical pathology
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Open AccessHER2 double-equivocal breast cancer in Chinese patients: a high concordance of HER2 status between different blocks from the same tumor
Human epidermal growth factor receptor 2 (HER2) status is both an independent prognostic factor and a predictive factor for the efficacy of targeted therapy for breast cancer, so it is critical to accurately d...
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Open AccessClinicopathological characteristics and molecular abnormalities of primary grade 2 neuroendocrine tumors of the cervix
Primary grade 2 neuroendocrine tumors of the cervix in female patients are rare and have a highly aggressive clinical course. This study is aimed to analyse the diagnosis, genetic changes, management and progn...
