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Article
Dynamic intrauterine crosstalk promotes porcine embryo implantation during early pregnancy
Dynamic crosstalk between the embryo and mother is crucial during implantation. Here, we comprehensively profile the single-cell transcriptome of pig peri-implantation embryos and corresponding maternal endome...
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Article
Open AccessUterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantation
Most pregnancy losses worldwide are caused by implantation failure for which there is a lack of effective therapeutics. Extracellular vesicles are considered potential endogenous nanomedicines because of their...
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Article
Efficient deletion of LoxP-flanked selectable marker genes from the genome of transgenic pigs by an engineered Cre recombinase
Genetically modified (GM) pigs hold great promises for pig genetic improvement, human health and life science. When GM pigs are produced, selectable marker genes (SMGs) are usually introduced into their genome...
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Article
Co-expression of fat1 and fat2 in transgenic pigs promotes synthesis of polyunsaturated fatty acids
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are essential for the development and health of mammals, such as humans and livestock. n-3 PUFAs must be supplied by diet due to the absence of a key gene, namel...
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Article
Pig transgenesis by piggyBac transposition in combination with somatic cell nuclear transfer
The production of animals by somatic cell nuclear transfer (SCNT) is inefficient, with approximately 2 % of micromanipulated oocytes going to term and resulting in live births. However, it is the most commonly...