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Article
Open AccessMechanochemical synthesis of organoselenium compounds
We disclose herein a strategy for the rapid synthesis of versatile organoselenium compounds under mild conditions. In this work, magnesium-based selenium nucleophiles are formed in situ from easily available o...
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Article
Application of modified cellulose nanocrystals as nonionic surfactant
A surfactant with biodegradability and amphiphilicity was prepared from cellulose nanocrystals by grafting fatty acids. The structure of the modified cellulose nanocrystals was investigated by infrared spectro...
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Article
Open AccessStructural basis for FGF hormone signalling
α/βKlotho coreceptors simultaneously engage fibroblast growth factor (FGF) hormones (FGF19, FGF21 and FGF23)1,2 and their cognate cell-surface FGF receptors (FGFR1–4) thereby stabilizing the endocrine FGF–FGFR co...
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Article
Open AccessComprehensive analysis of oncogenic fusions in mismatch repair deficient colorectal carcinomas by sequential DNA and RNA next generation sequencing
Colorectal carcinoma (CRC) harboring oncogenic fusions has been reported to be highly enriched in mismatch repair deficient (dMMR) tumors with MLH1 hypermethylation (MLH1me+) and wild-type BRAF and RAS. In this s...
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Article
Evalution of surface activity of hydrophobic modified nanocrystalline cellulose
Nanocrystalline cellulose (NCC) prepared via sulfuric acid hydrolysis was used as raw material. The nanocrystalline cellulose was graft-modified by long-chain fatty acids including lauric acid, palmitic acid, ...
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Article
Open AccessNew exact solutions for Kudryashov–Sinelshchikov equation
In this paper, we firstly change the auxiliary second order ordinary differential equation in the ...
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Article
Open AccessPD-L1 in pancreatic ductal adenocarcinoma: a retrospective analysis of 373 Chinese patients using an in vitro diagnostic assay
Programmed death ligand 1 (PD-L1) has shown potential as a therapeutic target in numerous solid tumors. Its prognostic significance has also been established in pancreatic ductal adenocarcinoma (PDAC). The pre...
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Article
Open AccessExpression of signaling adaptor proteins predicts poor prognosis in pancreatic ductal adenocarcinoma
Adaptor proteins bridge the gap between cell surface receptors and their downstream signaling elements. The clinicopathological and prognostic values of adaptor proteins remain poorly understood. The purpose o...
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Article
Design and Implementation of Portable Device Based Mobile Medical Service System
By the way of the mobile wireless network, portable devices have been widely used to obtain the online resources than before. Based on portable device, it can provide access points to get the necessary informa...
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Chapter and Conference Paper
A Hybrid Algorithm Based on Particle Swarm Optimization and Ant Colony Optimization Algorithm
Particle swarm optimization (PSO) and Ant Colony Optimization (ACO) are two important methods of stochastic global optimization. PSO has fast global search capability with fast initial speed. But when it is cl...
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Article
c-Met and ERβ expression differences in basal-like and non-basal-like triple-negative breast cancer
Basal-like breast cancer (BLBC) and triple-negative breast cancer (TNBC) are two entities of breast cancer that share similar poor prognosis. Even though both cancers have overlaps, there are still some differ...
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Article
Open AccessExpression of amphiregulin predicts poor outcome in patients with pancreatic ductal adenocarcinoma
The validation of novel diagnostic, prognostic and predictive biomarkers in cancer is crucial for optimizing the choice and efficacy of personalized therapies. The aim of this study was to determine the epider...
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Article
Open AccessScreening for major driver oncogene alterations in adenosquamous lung carcinoma using PCR coupled with next-generation and Sanger sequencing methods
We investigated the frequency of major driver oncogenes in lung adenosquamous cell carcinoma (ASC) cases. Frequency of EGFR, K-Ras, B-Raf, PIK3CA, DDR2, ALK, and PDGFRA gene mutations was examined in 56 patients ...
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Article
Mutant-specific BRAF and CD117 immunocytochemistry potentially facilitate risk stratification for papillary thyroid carcinoma in fine-needle aspiration biopsy specimens
The study aims to test whether combination of mutant-specific BRAF and CD117 immunocytochemical (ICC) staining stratifies probability for papillary thyroid carcinoma (PTC) in thyroid fine-needle aspiration bio...
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Article
Open AccessMolecular spectrum of KRAS, NRAS, BRAF and PIK3CA mutations in Chinese colorectal cancer patients: analysis of 1,110 cases
Mutations in genes such as KRAS, NRAS, BRAF and PIK3CA have become an important part of colorectal carcinoma evaluation. The aim of this study was to screen for mutations in these genes in Chinese patients wit...
