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Article
Open AccessSmall heterodimer partner interacting leucine zipper protein (SMILE) ameliorates autoimmune arthritis via AMPK signaling pathway and the regulation of B cell activation
Rheumatoid arthritis (RA) is an autoimmune disease that causes joint swelling and inflammation and can involve the entire body. RA is characterized by the increase of pro-inflammatory cytokines such as interle...
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Article
Efficient two-dimensional Haar \(^+\) synopsis construction for the maximum absolute error measure
Several wavelet synopsis construction algorithms were previously proposed for optimal Haar \(^+\) ...
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Article
Open AccessRIPK1 inhibition attenuates experimental autoimmune arthritis via suppression of osteoclastogenesis
Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disease characterized by upregulation of inflammatory cell death and osteoclastogenesis. Necrostatin (NST)-1s is a chemical inhibitor of recepto...
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Article
An efficient parallel similarity matrix construction on MapReduce for collaborative filtering
Nowadays, the collaborative filtering becomes popular for recommendation systems. However, as the volume of data increases expansively, the construction of a similarity matrix becomes a performance bottleneck ...
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Article
Open AccessKaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic inflammatory disease that mainly affects the synovial joints. Although involvement of the fibroblast growth factor (FGF) signaling pathway has been suggested as an impor...
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Article
Open AccessThe active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1
Leflunomide is a low-molecular-weight compound that is widely used in the treatment of rheumatoid arthritis. Although leflunomide is thought to act through the inhibition of the de novo pyrimidine synthesis, t...
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Article
Open AccessIK acts as an immunoregulator of inflammatory arthritis by suppressing TH17 cell differentiation and macrophage activation
Pathogenic T helper cells (TH) and macrophages have been implicated in the development of rheumatoid arthritis (RA), which can lead to severe synovial inflammation and bone destruction. A range of therapies have ...
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Article
Open AccessHtrA2 suppresses autoimmune arthritis and regulates activation of STAT3
Rheumatoid arthritis (RA) is an autoimmune disease that is related to the induction of T helper (Th)17 cells, which secrete interleukin-17, and activation of the signal transducer and activator of transcriptio...
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Article
Open AccessOverexpression of soluble RAGE in mesenchymal stem cells enhances their immunoregulatory potential for cellular therapy in autoimmune arthritis
Mesenchymal stem cells (MSCs) are attractive agents for cellular therapy in rheumatoid arthritis (RA). The receptor for advanced glycation end products (RAGE) serves as a pattern recognition receptor for endog...
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Article
Open AccessErratum to: Amelioration of autoimmune arthritis by adoptive transfer of Foxp3-expressing regulatory B cells is associated with the Treg/Th17 cell balance
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Article
Open AccessAmelioration of autoimmune arthritis by adoptive transfer of Foxp3-expressing regulatory B cells is associated with the Treg/Th17 cell balance
Foxp3 is a key regulator of the development and function of regulatory T cells (Tregs), and its expression is thought to be T cell-restricted. We found that B cells in mice can express Foxp3 and B cells expres...
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Article
STX0119 ameliorates arthritis in SKG mice via inhibiting T helper 17
Rheumatoid arthritis (RA) is an autoimmune disease with chronic and excessive inflammation. Upregulation of interleukin (IL)-17 is involved in the pathogenesis of RA. STX0119 is a specific inhibitor of signal ...
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Chapter and Conference Paper
Efficient Data Monitoring in Sensor Networks Using Spatial Correlation
In order to reduce r the energy consumption of sensors, we present an approximate data gathering technique, called CMOS, based on the Kalman filter. The goal of CMOS is to efficiently obtain the sensor reading...
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Chapter and Conference Paper
An Efficient Outlier Detection Technique in Wireless Sensor Networks
An outlier in wireless sensor networks is a sensor reading generated by malfunctioned sensor nodes or external environmental effect. Since an outlier is an important indicator of environment change or malfunct...
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Article
Open AccessIn vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis
Interleukin (IL)-27 is a novel cytokine of the IL-6/IL-12 family that has been reported to be involved in the pathogenesis of autoimmune diseases and has a pivotal role as both a pro- and anti-inflammatory cyt...
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Article
Augmented chondroprotective effect of coadministration of celecoxib and rebamipide in the monosodium iodoacetate rat model of osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease characterized by the progressive loss of articular cartilage and chronic pain. Although cyclooxygenase-2 (COX-2) inhibitors such as celecoxib are recommended...
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Chapter and Conference Paper
An Efficient Data Access Method Exploiting Quadtrees on MapReduce Frameworks
Due to the advance of diverse techniques such as social networks and sensor networks, the volume of data to be processed has rapidly increased. After Google proposed the MapReduce framework which processes big...
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Article
Open AccessObesity aggravates the joint inflammation in a collagen-induced arthritis model through deviation to Th17 differentiation
White fat cells secrete adipokines that induce inflammation and obesity has been reported to be characterized by high serum levels of inflammatory cytokines such as IL-6 and TNF-α. Rheumatoid arthritis (RA) is...
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Article
Open AccessGrape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis
Osteoarthritis (OA) is an age-related joint disease that is characterized by degeneration of articular cartilage and chronic pain. Oxidative stress is considered one of the pathophysiological factors in the pr...
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Article
Open AccessRegulation of B cell activating factor (BAFF) receptor expression by NF-κB signaling in rheumatoid arthritis B cells
B cells play an important role in the pathogenesis of rheumatoid arthritis (RA). High levels of B cell activating factor (BAFF) are detected in autoimmune diseases. BAFF and BAFF receptor (BAFF-R) are expresse...
