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  1. Article

    Open Access

    Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion

    Cancer genetics has uncovered many tumor-suppressor and oncogenic pathways, but few alterations have revealed mechanisms involved in tumor spreading. Here, we examined the role of the third most significant ch...

    Julien Ablain, Amira Al Mahi, Harriet Rothschild, Meera Prasad… in Nature Genetics (2022)

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  2. Article

    Open Access

    Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma

    Genome-wide association studies (GWAS) have identified ~20 melanoma susceptibility loci, most of which are not functionally characterized. Here we report an approach integrating massively-parallel reporter ass...

    Jiyeon Choi, Tongwu Zhang, Andrew Vu, Julien Ablain… in Nature Communications (2020)

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  3. No Access

    Article

    Zebrafish patient avatars in cancer biology and precision cancer therapy

    In precision oncology, two major strategies are being pursued for predicting clinically relevant tumour behaviours, such as treatment response and emergence of drug resistance: inference based on genomic, tran...

    Maurizio Fazio, Julien Ablain, Yan Chuan, David M. Langenau… in Nature Reviews Cancer (2020)

  4. No Access

    Chapter

    PML/RARA as the Master Driver of APL Pathogenesis and Therapy Response

    Acute promyelocytic leukemia (APL) is a model disease for targeted therapy. APL is caused by a variety of fusion proteins, all implicating the retinoic acid receptor alpha (RARA). The promyelocytic gene (PML)/...

    Hugues de Thé, Jun Zhu, Rihab Nasr… in Targeted Therapy of Acute Myeloid Leukemia (2015)

  5. No Access

    Article

    Activation of a promyelocytic leukemia–tumor protein 53 axis underlies acute promyelocytic leukemia cure

    Retinoic acid and arsenic therapies have shown considerable efficacy in patients with acute promyelocytic leukemia, but their exact mechanism of action remains unclear. Here, Hugues de Thé and colleagues uncov...

    Julien Ablain, Kim Rice, Hassane Soilihi, Aurélien de Reynies… in Nature Medicine (2014)