12 Result(s)
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Julia Carrasco-Zanini
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Open AccessMulti-omic prediction of incident type 2 diabetes
The identification of people who are at high risk of develo** type 2 diabetes is a key part of population-level prevention strategies. Previous studies have evaluated the predictive utility of omics measurem...
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Open AccessProteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
Human plasma contains a wide variety of circulating proteins. These proteins can be important clinical biomarkers in disease and also possible drug targets. Large scale genomics studies of circulating proteins...
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Open AccessCirculating proteins to predict COVID-19 severity
Predicting COVID-19 severity is difficult, and the biological pathways involved are not fully understood. To approach this problem, we measured 4701 circulating human protein abundances in two independent coho...
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Author Correction: Proteogenomic links to human metabolic diseases
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Proteogenomic links to human metabolic diseases
Studying the plasma proteome as the intermediate layer between the genome and the phenome has the potential to identify new disease processes. Here, we conducted a cis-focused proteogenomic analysis of 2,923 plas...
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Open AccessCorrection: The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals
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Proteomic signatures for identification of impaired glucose tolerance
The implementation of recommendations for type 2 diabetes (T2D) screening and diagnosis focuses on the measurement of glycated hemoglobin (HbA1c) and fasting glucose. This approach leaves a large number of ind...
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Open AccessThe dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals
Severe COVID-19 leads to important changes in circulating immune-related proteins. To date it has been difficult to understand their temporal relationship and identify cytokines that are drivers of severe COVI...
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Open AccessSynergistic insights into human health from aptamer- and antibody-based proteomic profiling
Affinity-based proteomics has enabled scalable quantification of thousands of protein targets in blood enhancing biomarker discovery, understanding of disease mechanisms, and genetic evaluation of drug targets...
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Open AccessAuthor Correction: Genetic architecture of host proteins involved in SARS-CoV-2 infection
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21370-6
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Open AccessGenetic architecture of host proteins involved in SARS-CoV-2 infection
Understanding the genetic architecture of host proteins interacting with SARS-CoV-2 or mediating the maladaptive host response to COVID-19 can help to identify new or repurpose existing drugs targeting those p...
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Open AccessIntegrating Genetics and the Plasma Proteome to Predict the Risk of Type 2 Diabetes
Proteins are the central layer of information transfer from genome to phenome and represent the largest class of drug targets. We review recent advances in high-throughput technologies that provide comprehensi...
